VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity (Q40331909)

19 September 2017

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title

VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity (English)

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19 September 2017

J D Loike

1

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19 September 2017

1 January 1982

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Cancer Chemotherapy and Pharmacology

19 September 2017

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19 September 2017

7

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19 September 2017

2-3

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19 September 2017

103-111

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https://scigraph.springernature.com/pub.10.1007/bf00254530

19 September 2017

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cites work

Kinetic and steady-state analysis of microtubules in the presence of colchicine

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12 December 2020

Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners

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12 December 2020

Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture

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12 December 2020

Podophyllotoxin derivative VP 16-213

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12 December 2020

Opposite end assembly and disassembly of microtubules at steady state in vitro

1 reference

12 December 2020

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1 reference

12 December 2020

Structure of the mitotic spindle inhibitor colcemid. N-desacetyl-N-methylcolchicine

1 reference

12 December 2020

Comparison of the human pharmacokinetics of VM-26 and VP-16, two antineoplastic epipodophyllotoxin glucopyranoside derivatives

1 reference

12 December 2020

VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules

1 reference

12 December 2020

The effect of podophyllin cytostatics SP-I and SP-G on the proliferation and respiration of HeLa cells in vitro

1 reference

12 December 2020

Analysis of the anticancer drugs VP 16-213 and VM 26 and their metabolites by high-performance liquid chromatography

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12 December 2020

4′-Demethyl-epipodophyllotoxin thenylidene glucoside (VM 26), a podophyllum compound with a new mechanism of action

1 reference

12 December 2020

Effect of podophyllotoxin, alpha-peltatin and beta-peltatin on the cytochrome oxidase activity of sarcoma 37

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12 December 2020

Etoposide (VP-16-213)

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12 December 2020

Effects of a new antitumor agent, epipodophyllotoxin, on growth and chromosomes in human hematopoietic cell lines.

1 reference

12 December 2020

Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations

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12 December 2020

Cell motility by labile association of molecules. The nature of mitotic spindle fibers and their role in chromosome movement

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12 December 2020

Colchicine inhibition of microtubule assembly via copolymer formation

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12 December 2020

Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors.

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12 December 2020

Incorporation of radioactive tubulin into microtubules at steady state. Experimental and theoretical analysis of the effect of podophyllotoxin

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12 December 2020

The effect of podophyllotoxin on tissue metabolism and enzyme systems

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12 December 2020

Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells

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12 December 2020

Chemotherapy of small cell carcinoma of the lung with V. P. 16–213

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12 December 2020

A quantitative microdensitometric and autoradiographic study of the effect of 4?-demethyl-epipodophyllotoxin-?-D-thenylidene glucoside (VM-26) on the cell cycle of cultured fibroblasts

1 reference

12 December 2020

Comparison of uptake and binding of two epipodophyllotoxin glucopyranosides, 4'-demethyl epipodophyllotoxin thenylidene-beta-D-glucoside and 4'-demethyl epipodophyllotoxin ethylidene-beta-D-glucoside, in the L1210 leukemia cell

1 reference

12 December 2020

Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly

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12 December 2020

Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages

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12 December 2020

Uridine transport in novikoff rat hepatoma cells and other cell lines and its relationship to uridine phosphorylation and phosphorolysis

1 reference

12 December 2020

Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines

1 reference

12 December 2020

Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures

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12 December 2020

Thymidine transport in cultured mammalian cells. Kinetic analysis, temperature dependence and specificity of the transport system

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12 December 2020

Sedimentation of DNA from L1210 cells after treatment with 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) or 1-beta-D-arabinofuranosylcytosine or both drugs

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12 December 2020

Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts

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12 December 2020

Tubulin binding affinities of podophyllotoxin and colchicine analogues

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12 December 2020

Mediated transport of nucleosides in human erythrocytes. Accelerative exchange diffusion of uridine and thymidine and specificity toward pyrimidine nucleosides as permeants

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12 December 2020

The biological effects and the chemical composition of podophyllin: a review

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12 December 2020

Multicompartment pharmacokinetic model of 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside) in humans

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12 December 2020

Effect of an epipodophyllotoxin derivative (VP 16-213) on macromolecular synthesis and mitosis in mastocytoma cells in vitro.

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12 December 2020

Inhibition of uridine uptake in HeLa cells by nitrobenzylthioinosine and related compounds

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12 December 2020

Low specificity of the nucleoside transport mechanism of RPMI 6410 cells

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12 December 2020

Nucleoside transport in mammalian cells. Inhibition by colchicine

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12 December 2020

Inhibition of NADH-linked respiration with the anti-cancer agent 4'-demethyl-epipodophyllotoxin thenylidene glucoside (VM-26)

1 reference

12 December 2020

Combined VM-26 and cytosine arabinoside in treatment of refractory childhood lymphocytic leukemia

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12 December 2020

Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro

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12 December 2020

Identifiers

DOI

10.1007/BF00254530

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PubMed ID

7044591

Dimensions Publication ID

19 September 2017

0 references

1 reference

PubMed ID

7044591