Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors (Q40303556)

19 September 2017

Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors (English)

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19 September 2017

Brian L Jones

1

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19 September 2017

Paul J Whiting

series ordinal

2

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19 September 2017

Leslie P Henderson

series ordinal

3

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19 September 2017

language of work or name

English

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publication date

16 March 2006

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19 September 2017

Journal of Physiology

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19 September 2017

573

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19 September 2017

571-593

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19 September 2017

Pt 3

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Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit

19 September 2017

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Psychological and behavioural effects of endogenous testosterone and anabolic-androgenic steroids. An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Behavioral and physiological responses to anabolic-androgenic steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Endogenous GABA release inhibits the firing of adult gonadotropin-releasing hormone neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Morphine withdrawal increases expression of GABA(A) receptor epsilon subunit mRNA in locus coeruleus neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Role of medial preoptic GABA neurones in regulating luteinising hormone secretion in the ovariectomised rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Desensitized states prolong GABAA channel responses to brief agonist pulses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

The function and the expression of forebrain GABA(A) receptors change with hormonal state in the adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Statistical discrimination of fractal and Markov models of single-channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Neurosteroids and GABAA receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Neurosteroid modulation of GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

CNS effects and abuse liability of anabolic-androgenic steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Anabolic androgenic steroids induce age-, sex-, and dose-dependent changes in GABA(A) receptor subunit mRNAs in the mouse forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Direct effects of the anabolic/androgenic steroids, stanozolol and 17 alpha-methyltestosterone, on benzodiazepine binding to the. gamma-aminobutyric acid(a) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

A TM2 residue in the beta1 subunit determines spontaneous opening of homomeric and heteromeric gamma-aminobutyric acid-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Structure and gating mechanism of the acetylcholine receptor pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Mechanisms underlying episodic gonadotropin-releasing hormone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Gonadotropin-releasing hormone neurons generate interacting rhythms in multiple time domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Sex-specific effects of chronic anabolic androgenic steroid treatment on GABA(A) receptor expression and function in adolescent mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Tonically active GABA A receptors: modulating gain and maintaining the tone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Late postnatal reorganization of GABA(A) receptor signalling in native GnRH neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Modulation of GABA(A) receptor channel gating by pentobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Modulation of the GABAA receptor complex by steroids in slices of rat cuneate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Molecular and functional diversity of the expanding GABA-A receptor gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Mechanisms of anabolic androgenic steroid modulation of alpha(1)beta(3)gamma(2L) GABA(A) receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Role of the alpha subunit in the modulation of GABA(A) receptors by anabolic androgenic steroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology.

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Anabolic-androgenic steroid abuse and performance-enhancing drugs among adolescents.

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Endocrine aspects of anabolic steroids

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Relaxation and fluctuations of membrane currents that flow through drug-operated channels

14 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779744

Relaxation and Fluctuations of Membrane Currents that Flow through Drug-Operated Channels

14 September 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2006.106534

Estrogen regulation of GABAA receptor subunit mRNA expression in preoptic area and bed nucleus of the stria terminalis of female rat brain

21 January 2018

1 reference

12 December 2020

Effect of anabolic steroids on behavior and physiological characteristics of female mice

1 reference

12 December 2020

GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice

1 reference

12 December 2020

Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization

1 reference

12 December 2020

10.1113/JPHYSIOL.2006.106534

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DOI

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19 September 2017

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