Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor (Q40290597)

19 September 2017

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor (English)

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19 September 2017

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ChEBI release 2020-05-28

Shin-ichi Yaguchi

1

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19 September 2017

Yasuhisa Fukui

2

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19 September 2017

Ichiro Koshimizu

3

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19 September 2017

Hisashi Yoshimi

4

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19 September 2017

Toshiyuki Matsuno

5

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19 September 2017

Hiroaki Gouda

6

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19 September 2017

Shuichi Hirono

7

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19 September 2017

Kanami Yamazaki

8

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19 September 2017

Takao Yamori

9

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19 September 2017

language of work or name

English

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publication date

1 April 2006

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Journal of the National Cancer Institute

19 September 2017

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19 September 2017

98

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19 September 2017

8

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19 September 2017

545-556

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

19 September 2017

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

In vitro cytotoxicity of imidazolyl-1,3,5-triazine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

New colorimetric cytotoxicity assay for anticancer-drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

A fast flexible docking method using an incremental construction algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

A geometric approach to macromolecule-ligand interactions

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

A general and fast scoring function for protein-ligand interactions: a simplified potential approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJJ133

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJJ133

1 reference

19 September 2017

1 reference