TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis (Q40288010)

19 September 2017

TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis (English)

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19 September 2017

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Dumitru CA

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19 September 2017

Gulbins E

series ordinal

2

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19 September 2017

language of work or name

English

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publication date

24 April 2006

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19 September 2017

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19 September 2017

25

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19 September 2017

41

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19 September 2017

5612-5625

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209568

19 September 2017

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cites work

Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Safety and antitumor activity of recombinant soluble Apo2 ligand

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Apoptosis-modulating agents in combination with radiotherapy-current status and outlook

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Receptor-mediated choreography of life and death.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Structure and origin of ordered lipid domains in biological membranes.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Ceramide enables fas to cap and kill.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CD95 rapidly clusters in cells of diverse origins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Exploiting death receptor signaling pathways for tumor therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Ceramide-mediated clustering is required for CD95-DISC formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CD95 Signaling via Ceramide-rich Membrane Rafts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Ceramide-rich membrane rafts mediate CD40 clustering

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Molecular mechanisms of ceramide-mediated CD95 clustering

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Measurement of sphingomyelinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Structure-activity relationships of alkylphosphocholine derivatives: antineoplastic action on brain tumor cell lines in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Intracellular mediators of erucylphosphocholine-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Observation of Topical Catalysis by Sphingomyelinase Coupled To Microspheres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The receptor for the cytotoxic ligand TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Reactive oxygen species limit neutrophil life span by activating death receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

TRAIL/Apo-2 ligand induces primary plasma cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

CD40 signaling in human dendritic cells is initiated within membrane rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Identification and characterization of a new member of the TNF family that induces apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209568

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209568

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Dimensions Publication ID

19 September 2017

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