Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells (Q40284719)

19 September 2017

Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells (English)

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19 September 2017

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A Hill

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S McFarlane

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K Mulligan

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H Gillespie

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J E Draffin

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A Trimble

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A Ouhtit

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P G Johnston

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D P Harkin

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D McCormick

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D J J Waugh

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19 September 2017

language of work or name

English

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publication date

1 May 2006

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25

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6079-6091

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45

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209628

19 September 2017

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cites work

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Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

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Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation

21 January 2018

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CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration

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CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration

21 January 2018

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Cortactin promotes cell motility by enhancing lamellipodial persistence

21 January 2018

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Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

21 January 2018

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The hyaluronan receptor, CD44.

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Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy

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Hyaluronan: a multifunctional, megaDalton, stealth molecule

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Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis

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Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.

21 January 2018

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Epidermal growth factor up-regulates CD44-dependent astrocytoma invasion in vitro.

21 January 2018

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How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

21 January 2018

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Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth

21 January 2018

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Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength

21 January 2018

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Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor

21 January 2018

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Hyaluronan promotes the malignant phenotype

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ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

21 January 2018

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Activation of Arp2/3 complex-mediated actin polymerization by cortactin

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Cortactin overexpression results in sustained epidermal growth factor receptor signaling by preventing ligand-induced receptor degradation in human carcinoma cells

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Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

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21 January 2018

Cell migration in tumors

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The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation.

21 January 2018

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Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast

21 January 2018

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7 January 2021

CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells

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7 January 2021

Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells

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7 January 2021

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7 January 2021

CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells

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7 January 2021

Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells

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7 January 2021

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

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7 January 2021

The expression of variant exon v7-v8 CD44 antigen in relation to lymphatic metastasis of human breast cancer

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7 January 2021

The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209628

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Dimensions Publication ID

19 September 2017

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