Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. (Q40278299)

19 September 2017

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. (English)

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19 September 2017

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19 September 2017

Nicolas Casadei

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Doron Rapaport

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Doron Rapaport

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Silke Nuber

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Olaf Riess

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Rejko Krüger

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Poonam Sood

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Thomas Ulrich

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Petra Fallier-Becker

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Nicole Kieper

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Stefan Helling

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Caroline May

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Jing Chen

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Katrin Marcus

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Thomas Ott

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Julia C Fitzgerald

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24 November 2015

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Human Molecular Genetics

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19 September 2017

459-471

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

19 September 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Quality control of mitochondrial proteostasis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

The HtrA Family of Proteases

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Transgenic mice with neuron-specific overexpression of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Sfold web server for statistical folding and rational design of nucleic acids

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

A rotarod test for evaluation of motor skill learning

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Alterations in the mitochondrial proteome of neuroblastoma cells in response to complex 1 inhibition.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Enrichment of single neurons and defined brain regions from human brain tissue samples for subsequent proteome analysis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative proteomics study.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Controlling the false discovery rate in behavior genetics research

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Vienna RNA secondary structure server

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

Mfold web server for nucleic acid folding and hybridization prediction

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV485

21 January 2018

Identifiers

DOI

10.1093/HMG/DDV485

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19 September 2017

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