AMPK: mediating the metabolic effects of salicylate-based drugs? (Q40240715)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23871515%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

AMPK: mediating the metabolic effects of salicylate-based drugs? (English)

1 reference

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5 March 2020

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ChEBI release 2020-05-28

2

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5 March 2020

Grahame Hardie

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23871515%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Gregory R Steinberg

series ordinal

1

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5 March 2020

language of work or name

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19 July 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23871515%20AND%20SRC:MED&resulttype=core&format=json

Trends in Endocrinology and Metabolism

5 March 2020

published in

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5 March 2020

volume

24

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5 March 2020

issue

10

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5 March 2020

page(s)

481-487

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Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative

5 March 2020

cites work

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17 June 2018

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17 June 2018

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Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

17 June 2018

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Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study

17 June 2018

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17 June 2018

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Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis

17 June 2018

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The ancient drug salicylate directly activates AMP-activated protein kinase

17 June 2018

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Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

17 June 2018

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

17 June 2018

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The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

17 June 2018

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AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

17 June 2018

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Structure of mammalian AMPK and its regulation by ADP

17 June 2018

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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

17 June 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

17 June 2018

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Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

17 June 2018

1 reference

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Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

17 June 2018

1 reference

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AMPK in Health and Disease

17 June 2018

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

17 June 2018

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Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

17 June 2018

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Salicylic Acid, a multifaceted hormone to combat disease.

17 June 2018

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Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

17 June 2018

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Salsalate improves glycemia and inflammatory parameters in obese young adults

17 June 2018

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5714185

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

17 June 2018

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Inflammation and insulin resistance

17 June 2018

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Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

17 June 2018

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Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial

17 June 2018

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Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes

17 June 2018

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IKK-beta links inflammation to obesity-induced insulin resistance

17 June 2018

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

17 June 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

17 June 2018

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

17 June 2018

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Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8.

17 June 2018

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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

17 June 2018

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5714185

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5714185

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5714185

17 June 2018

Cyclooxygenases 1 and 2

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

17 June 2018

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Inhibition of NF-kappa B by sodium salicylate and aspirin

17 June 2018

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

17 June 2018

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Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity

17 June 2018

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Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis

17 June 2018

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AMPK is a direct adenylate charge-regulated protein kinase.

17 June 2018

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Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.

20 August 2018

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Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions

20 August 2018

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Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

20 August 2018

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Metformin suppresses intestinal polyp growth in ApcMin/+ mice

20 August 2018

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

20 August 2018

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Inhibition of hepatic lipogenesis by salicylate

20 August 2018

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12 December 2020

Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism

1 reference

12 December 2020

Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level

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12 December 2020

Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ

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12 December 2020

10.1016/J.TEM.2013.06.002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23871515%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23871515%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23871515

1 reference