Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance (Q40222429)

18 September 2017

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance (English)

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18 September 2017

11

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18 September 2017

Malcolm Walkinshaw

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author name string

Campbell McInnes

1

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18 September 2017

Aveek Mazumdar

2

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18 September 2017

Mokdad Mezna

3

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18 September 2017

Christopher Meades

4

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18 September 2017

Carol Midgley

5

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18 September 2017

Fred Scaerou

6

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18 September 2017

Lee Carpenter

7

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18 September 2017

Mairi Mackenzie

8

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18 September 2017

Paul Taylor

9

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18 September 2017

David Glover

12

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18 September 2017

8 October 2006

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18 September 2017

Nature Chemical Biology

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18 September 2017

2

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18 September 2017

608-617

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18 September 2017

11

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https://scigraph.springernature.com/pub.10.1038/nchembio825

18 September 2017

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cites work

Progress in the discovery of polo-like kinase inhibitors.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Polo-box motif targets a centrosome regulator, RanGTPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Getting in and out of mitosis with Polo-like kinase-1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

POLO kinase regulates the Drosophila centromere cohesion protein MEI-S332.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Drosophila polo kinase is required for cytokinesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Genome-wide survey of protein kinases required for cell cycle progression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Metaphase arrest with centromere separation in polo mutants of Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Antagonistic activities of Klp10A and Orbit regulate spindle length, bipolarity and function in vivo.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Organized microtubule arrays in gamma-tubulin-depleted Drosophila spermatocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Polar expeditions--provisioning the centrosome for mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO825

Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

polo encodes a protein kinase homolog required for mitosis in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Polo-like kinases: a team that plays throughout mitosis

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Tumor regression by combination antisense therapy against Plk1 and Bcl-2

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

SAK/PLK4 is required for centriole duplication and flagella development

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https://api.crossref.org/works/10.1038%2FNCHEMBIO825

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO825

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18 September 2017

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