Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus (Q40174110)

18 September 2017

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title

Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus (English)

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18 September 2017

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D. H. Lockwood

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6369965

10 October 2023

J. M. Amatruda

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6369965

10 October 2023

language of work or name

English

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publication date

1 November 1983

1 reference

18 September 2017

30 November 1983

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6369965

full work available at URL

10 October 2023

https://api.elsevier.com/content/article/PII:0002934383902504?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

https://api.elsevier.com/content/article/PII:0002934383902504?httpAccept=text/plain

10 October 2023

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

American Journal of Medicine

10 October 2023

published in

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18 September 2017

75

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18 September 2017

5B

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18 September 2017

23-31

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Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism

18 September 2017

1

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Splanchnic glucose and amino acid metabolism in obesity

10 October 2023

2

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction

10 October 2023

4

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization

10 October 2023

5

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin-induced alterations in insulin binding and insulin action in primary cultures of rat hepatocytes

10 October 2023

6

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Direct measurements of sugar uptake in small and large adipocytes from young and adult rats

10 October 2023

8

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Biochemical basis of fat cell insulin resistance in obese rodents and man

10 October 2023

9

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin Insensitivity of Large Fat Cells

10 October 2023

10

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effect of Fasting and Streptozotocin in the Obese-hyperglycemic (ob/ob) Mouse: Apparent Lack of a Direct Relationship Between Insulin Binding and Insulin Effects

10 October 2023

12

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice

10 October 2023

13

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin binding and effects in isolated soleus muscle of lean and obese mice

10 October 2023

14

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Longitudinal Study on the Establishment of Insulin Resistance in Hypothalamic Obese Mice*

10 October 2023

15

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats

10 October 2023

16

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin and Glucagon-Receptor Interactions in the Genetically Obese Zucker Rat: Studies of Hormone Binding and Glucagon-Stimulated Cyclic AMP Levels in Isolated Hepatocytes1

10 October 2023

17

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin response in skeletal muscle and fat cells of the genetically obese Zucker rat

10 October 2023

18

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites

10 October 2023

19

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Glucose metabolism in perfused skeletal muscle. Demonstration of insulin resistance in the obese Zucker rat

10 October 2023

20

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction

10 October 2023

21

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin Receptor: Role in the Resistance of Human Obesity to Insulin

10 October 2023

22

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Decreased insulin binding to adipocytes and circulating monocytes from obese subjects

10 October 2023

23

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects

10 October 2023

24

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin Receptor Binding in Obesity: A Reassessment

10 October 2023

25

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin receptor binding and insulin action in human fat cells: effects of obesity and fasting

10 October 2023

26

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

10 October 2023

27

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Influence of obesity on the antilipolytic effect of insulin in isolated human fat cells obtained before and after glucose ingestion

10 October 2023

28

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Relationship between in Vivo Insulin Resistance and Decreased Insulin Receptors in Obese Man*

10 October 2023

29

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects

10 October 2023

30

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin control of glucose metabolism in man: a new kinetic analysis

10 October 2023

31

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity

10 October 2023

32

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity

10 October 2023

33

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size

10 October 2023

34

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation

10 October 2023

36

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The Influence of Obesity and Diabetes in the Monkey on Insulin and Glucagon Binding to Liver Membranes*

10 October 2023

37

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Studies of liver insulin receptors in non-obese and obese human subjects

10 October 2023

38

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin receptors in hepatocytes: postreceptor events mediate down regulation.

10 October 2023

39

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin receptor down-regulation, prevention at a post-receptor site

10 October 2023

40

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Energy-dependent steps in insulin-hepatocyte interaction

10 October 2023

41

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Influence of ambient glucose and insulin concentrations on adipocyte insulin binding

10 October 2023

42

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Glucocorticoid-induced insulin resistance: the importance of postbinding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat hepatocytes

10 October 2023

43

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Postreceptor defects causing insulin resistance in normoinsulinemic non-insulin-dependent diabetes mellitus.

10 October 2023

44

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin receptors and insulin resistance in human pregnancy: evidence for a postreceptor defect in insulin action.

10 October 2023

45

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The insulin receptor: its role in insulin resistance of obesity and diabetes

10 October 2023

46

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats.

10 October 2023

47

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats

10 October 2023

48

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin and glucagon binding and stimulation of amino acid transport in isolated hepatocytes from streptozotocin diabetic rats

10 October 2023

49

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Reduced glucose transport and increased binding of insulin in adipocytes from diabetic and fasted rats

10 October 2023

51

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

10 October 2023

52

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effect of Fasting and Streptozotocin Diabetes on Insulin Binding and Action in the Isolated Mouse Soleus Muscle

10 October 2023

53

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase

10 October 2023

55

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Immunoassay of endogenous plasma insulin in man

10 October 2023

56

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

10 October 2023

57

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia

10 October 2023

58

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?

10 October 2023

59

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes.

10 October 2023

60

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus.

10 October 2023

61

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The pathogenic role of an insulin-receptor defect in diabetes mellitus of the obese

10 October 2023

62

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus

10 October 2023

63

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes

10 October 2023

64

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Endocrine and metabolic effects of experimental obesity in man

10 October 2023

65

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects

10 October 2023

66

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

10 October 2023

67

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Maturity onset diabetes mellitus: response to intensive dietary management

10 October 2023

68

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics.

10 October 2023

69

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Increased insulin sensitivity and cellular insulin binding in obese diabetics following treatment with glibenclamide

10 October 2023

70

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels

10 October 2023

71

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Effect of insulin therapy on insulin resistance in type II diabetic subjects. Evidence for heterogeneity.

10 October 2023

72

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

Insulin treatment reverses the insulin resistance of type II diabetes mellitus.

10 October 2023

73

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

The effect of chronic sulfonylurea therapy on hepatic glucose production in non-insulin-dependent diabetes.

10 October 2023

75

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus

10 October 2023

76

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

In vitro effects of a sulfonylurea on insulin action in adipocytes. Potentiation of insulin-stimulated hexose transport

10 October 2023

78

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90250-4

10 October 2023

Identifiers

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18 September 2017

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