EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes (Q40156909)

18 September 2017

EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes (English)

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18 September 2017

2

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18 September 2017

Michael V Grandal

1

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18 September 2017

Mikkel W Pedersen

3

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18 September 2017

Berthe M Willumsen

4

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18 September 2017

Bo van Deurs

5

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18 September 2017

Hans S Poulsen

6

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18 September 2017

language of work or name

English

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publication date

19 March 2007

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18 September 2017

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18 September 2017

28

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18 September 2017

1408-1417

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18 September 2017

7

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The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target.

18 September 2017

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Expression of constitutively activated EGFRvIII in non-small cell lung cancer

21 January 2018

1 reference

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Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility

21 January 2018

1 reference

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Analysis of the epidermal growth factor receptor specific transcriptome: effect of receptor expression level and an activating mutation

21 January 2018

1 reference

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Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII.

21 January 2018

1 reference

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An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

21 January 2018

1 reference

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EGF mutant receptor vIII as a molecular target in cancer therapy

21 January 2018

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis

21 January 2018

1 reference

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Epidermal growth factor receptor mutation type III transfected into a small cell lung cancer cell line is predominantly localized at the cell surface and enhances the malignant phenotype

21 January 2018

1 reference

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Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells

21 January 2018

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The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

21 January 2018

1 reference

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Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function

21 January 2018

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Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly.

21 January 2018

1 reference

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Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Association and colocalization of Eps15 with adaptor protein-2 and clathrin

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

The antibody-induced clustering and endocytosis of HLA antigens on cultured human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Association with membrane protrusions makes ErbB2 an internalization-resistant receptor

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

1 reference

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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM058

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGM058

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18 September 2017

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