Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method (Q40113363)

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English	Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method	scientific article

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scholarly article

1 reference

17 September 2017

Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method (English)

1 reference

17 September 2017

author name string

Tikhonov DB

1

1 reference

17 September 2017

Zhorov BS

2

1 reference

17 September 2017

language of work or name

0 references

publication date

1 January 1998

1 reference

17 September 2017

Biophysical Journal

1 reference

17 September 2017

74

1 reference

17 September 2017

242-255

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17 September 2017

1

1 reference

17 September 2017

The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Neuronal nicotinic receptors: molecular organization and regulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Monovalent and divalent cation permeability and block of neuronal nicotinic receptor channels in rat parasympathetic ganglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Beta-structure in the membrane-spanning part of the nicotinic acetylcholine receptor (or how helical are transmembrane helices?).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

The permeability of the endplate channel to organic cations in frog muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

A comparison between mechanisms of action of different nicotinic blocking agents on rat submandibular ganglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

MK-801 inhibition of nicotinic acetylcholine receptor channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

The permeation pathway of neurotransmitter-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Threonine in the selectivity filter of the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Local anaesthetics transiently block currents through single acetylcholine-receptor channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

Voltage jump analysis of procaine action at frog end-plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

22 September 2017

The selectivity filter of a ligand-gated ion channel. The helix-M2 model of the ion channel of the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

25 September 2017

A mixed helix-beta-sheet model of the transmembrane region of the nicotinic acetylcholine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Structural model of a synthetic Ca2+ channel with bound Ca2+ ions and dihydropyridine ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Projection structure of the nicotinic acetylcholine receptor: distinct conformations of the alpha subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Voltage dependencies of the effects of chlorpromazine on the nicotinic receptor channel from mouse muscle cell line So18.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Calcium permeability of neuronal nicotinic acetylcholine receptor channels in PC12 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Conformational preferences of amino acids in globular proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

15 June 2018

Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore-lining structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

Fourier transform infrared and hydrogen/deuterium exchange reveal an exchange-resistant core of alpha-helical peptide hydrogens in the nicotinic acetylcholine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1299378

20 August 2018

Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Architecture of the neuronal nicotinic acetylcholine receptor ion channel at the binding site of bis-ammonium blockers

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Desensitization at the frog neuromuscular junction: a biphasic process

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

A possible model for the inner wall of the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Bundles of amphipathic transmembrane alpha-helices as a structural motif for ion-conducting channel proteins: studies on sodium channels and acetylcholine receptors

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https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Kinked structures of isolated nicotinic receptor M2 helices: a molecular dynamics study

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https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Nicotinic acetylcholine receptor at 9 A resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Acetylcholine receptor channel imaged in the open state

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Comparison of lowest energy conformations of dimethylcurine and methoxyverapamil: evidence of ternary association of calcium channel, Ca2+, and calcium entry blockers

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https://api.crossref.org/works/10.1016%2FS0006-3495%2898%2977783-5

7 January 2021

Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants

1 reference

https://pubmed.ncbi.nlm.nih.gov/9449326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phencyclidine and its analogs on the end-plate current of the neuromuscular junction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9449326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hydrophobic photoreagent 3-(trifluoromethyl)-3-m-([125I] iodophenyl) diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9449326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S0006-3495(98)77783-5

1 reference

17 September 2017

1 reference

17 September 2017

1 reference

17 September 2017

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