Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus (Q40111393)

17 September 2017

title

Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus (English)

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17 September 2017

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Raki M

1

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17 September 2017

Hakkarainen T

2

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17 September 2017

Bauerschmitz GJ

3

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17 September 2017

Särkioja M

4

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17 September 2017

Desmond RA

5

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17 September 2017

Kanerva A

6

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17 September 2017

Hemminki A

7

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17 September 2017

publication date

5 July 2007

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17 September 2017

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17 September 2017

volume

14

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17 September 2017

issue

19

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17 September 2017

page(s)

1380-1388

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302992

17 September 2017

exact match

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Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain

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CD46 represents a target for adenoviral gene therapy of malignant glioma.

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A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells.

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Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points

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7 January 2021

Armed therapeutic viruses: strategies and challenges to arming oncolytic viruses with therapeutic genes

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Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer

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7 January 2021

Influence of the bystander effect on HSV-tk/GCV gene therapy. A review

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7 January 2021

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

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An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

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Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapies

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Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region

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Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus

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VP22 does not significantly enhance enzyme prodrug cancer gene therapy as a part of a VP22-HSVTk-GFP triple fusion construct.

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Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

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Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk

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Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy

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7 January 2021

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

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p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

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Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

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7 January 2021

Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

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7 January 2021

Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

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Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer.

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An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

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Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.

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7 January 2021

Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954.

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7 January 2021

CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor--armed oncolytic adenovirus for the treatment of bladder cancer

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Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy

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7 January 2021

A simplified system for generating recombinant adenoviruses

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302992

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Dimensions Publication ID

17 September 2017

1000855787

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1 reference