SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. (Q40082412)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28834754%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28834754%20AND%20SRC:MED&resulttype=core&format=json

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

28 March 2020

main subject

1 reference

DNA strand resection involved in replication fork processing

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

PamelaSara E Head

4

1 reference

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28 March 2020

Erica Werner

8

1 reference

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28 March 2020

Donna Rose Whelan

12

1 reference

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28 March 2020

Eli Rothenberg

25

1 reference

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28 March 2020

Petr Cejka

24

0 references

William Dynan

object named as

William S Dynan

21

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author name string

Waaqo Daddacha

1

1 reference

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28 March 2020

Allyson E Koyen

2

1 reference

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28 March 2020

Amanda J Bastien

3

1 reference

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28 March 2020

Vishal R Dhere

5

1 reference

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28 March 2020

Geraldine N Nabeta

6

1 reference

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28 March 2020

Erin C Connolly

7

1 reference

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28 March 2020

Matthew Z Madden

9

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28 March 2020

Michele B Daly

10

1 reference

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28 March 2020

Elizabeth V Minten

11

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28 March 2020

Ashley J Schlafstein

13

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28 March 2020

Hui Zhang

14

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28 March 2020

Roopesh Anand

15

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28 March 2020

Christine Doronio

16

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28 March 2020

Allison E Withers

17

1 reference

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28 March 2020

Caitlin Shepard

18

1 reference

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28 March 2020

Ranjini K Sundaram

19

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28 March 2020

Xingming Deng

20

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28 March 2020

Ya Wang

22

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28 March 2020

Ranjit S Bindra

23

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28 March 2020

Paul W Doetsch

26

1 reference

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28 March 2020

Baek Kim

27

1 reference

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28 March 2020

David S Yu

28

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28 March 2020

publication date

1 August 2017

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28 March 2020

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28 March 2020

volume

20

1 reference

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28 March 2020

page(s)

1921-1935

1 reference

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28 March 2020

issue

8

1 reference

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Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

28 March 2020

cites work

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22 September 2017

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SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

22 September 2017

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Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

22 September 2017

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SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

22 September 2017

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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

22 September 2017

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ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.

22 September 2017

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22 September 2017

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Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair

22 September 2017

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22 September 2017

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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

22 September 2017

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Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins

22 September 2017

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Structural basis of cellular dNTP regulation by SAMHD1.

22 September 2017

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Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

22 September 2017

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A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response

22 September 2017

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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

22 September 2017

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Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection

22 September 2017

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CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity

22 September 2017

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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

22 September 2017

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CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer.

22 September 2017

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SAMHD1 prevents autoimmunity by maintaining genome stability

22 September 2017

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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

22 September 2017

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Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.

22 September 2017

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Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

22 September 2017

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Mechanism of allosteric activation of SAMHD1 by dGTP

22 September 2017

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SIRT2 directs the replication stress response through CDK9 deacetylation.

22 September 2017

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The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

22 September 2017

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Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

22 September 2017

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Single-stranded nucleic acids promote SAMHD1 complex formation

22 September 2017

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Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.

22 September 2017

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SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

22 September 2017

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Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages

22 September 2017

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22 September 2017

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CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks

22 September 2017

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SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

22 September 2017

1 reference

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

22 September 2017

1 reference

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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

22 September 2017

1 reference

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

22 September 2017

1 reference

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Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

22 September 2017

1 reference

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Double-strand break end resection and repair pathway choice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

22 September 2017

1 reference

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

22 September 2017

1 reference

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

22 September 2017

1 reference

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The MRE11 complex: starting from the ends.

22 September 2017

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Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.

22 September 2017

1 reference

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Cyclin-dependent kinase 9-cyclin K functions in the replication stress response

22 September 2017

1 reference

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Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

22 September 2017

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CtIP links DNA double-strand break sensing to resection

22 September 2017

1 reference

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The DNA-damage response in human biology and disease

22 September 2017

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N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair

22 September 2017

1 reference

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

22 September 2017

1 reference

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

22 September 2017

1 reference

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

22 September 2017

1 reference

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Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints

22 September 2017

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Human CtIP promotes DNA end resection

22 September 2017

1 reference

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Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

22 September 2017

1 reference

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BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy

22 September 2017

1 reference

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DNA end joining becomes less efficient and more error-prone during cellular senescence

22 September 2017

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

The HD domain defines a new superfamily of metal-dependent phosphohydrolases

22 September 2017

1 reference

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

SAM as a protein interaction domain involved in developmental regulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Single Molecule Localization Microscopy of DNA Damage Response Pathways in Cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5576576

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28834754

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2017.08.008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28834754%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28834754%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference