Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia (Q40075629)

17 September 2017

Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia (English)

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transcriptional dysregulation

17 September 2017

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17 September 2017

Tonks A

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17 September 2017

Pearn L

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17 September 2017

Musson M

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17 September 2017

Gilkes A

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Burnett AK

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17 September 2017

Darley RL

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27 September 2007

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2495-2505

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2404961

17 September 2017

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

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Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

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Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

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The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

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Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia revealed by microarray analysis

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The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor

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Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas

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CD200 is a new prognostic factor in multiple myeloma

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CD200 and membrane protein interactions in the control of myeloid cells

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CD200 as a prognostic factor in acute myeloid leukaemia.

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Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line

21 January 2018

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Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

21 January 2018

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21 January 2018

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

21 January 2018

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Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia

21 January 2018

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

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inferred from DOI database lookup

7 January 2021

based on heuristic

Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis

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inferred from DOI database lookup

7 January 2021

based on heuristic

Myelodysplasia and Naxos disease: a novel pathogenetic association?

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2404961

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Dimensions Publication ID

17 September 2017

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