Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation (Q40023882)

16 September 2017

Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation (English)

1 reference

16 September 2017

Maikel P Peppelenbosch

object named as

Maikel P Peppelenbosch

5

0 references

author name string

Keren Borensztajn

1

1 reference

16 September 2017

Jurriën Stiekema

2

1 reference

16 September 2017

Sebastiaan Nijmeijer

3

1 reference

16 September 2017

Pieter H Reitsma

4

1 reference

16 September 2017

C Arnold Spek

6

1 reference

16 September 2017

language of work or name

English

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publication date

17 January 2008

1 reference

The American Journal of Pathology

16 September 2017

1 reference

16 September 2017

172

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16 September 2017

2

1 reference

16 September 2017

309-320

1 reference

Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

22 September 2017

1 reference

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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

YB-1 coordinates vascular smooth muscle alpha-actin gene activation by transforming growth factor beta1 and thrombin during differentiation of human pulmonary myofibroblasts

22 September 2017

1 reference

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Blood coagulation and the risk of atherothrombosis: a complex relationship

22 September 2017

1 reference

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Protease-activated receptors: contribution to physiology and disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis

22 September 2017

1 reference

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Wound healing: an overview of acute, fibrotic and delayed healing

22 September 2017

1 reference

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Coagulation factors VIIa and Xa inhibit apoptosis and anoikis

22 September 2017

1 reference

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Factor Xa induces mitogenesis of vascular smooth muscle cells via autocrine production of epiregulin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis

22 September 2017

1 reference

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Coagulation, fibrinolysis, and fibrin deposition in acute lung injury

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Myofibroblasts and mechano-regulation of connective tissue remodelling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Mechanisms of myofibroblast activity and phenotypic modulation.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Transforming growth factor beta in tissue fibrosis

22 September 2017

1 reference

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Fibrin deposition in the kidney in post-ischaemic renal damage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

The molecular basis of blood coagulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Fibronectin. A versatile matrix protein with roles in thoracic development, repair and infection

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Intramural delivery of Sirolimus prevents vascular remodeling following balloon injury.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Protease-activated receptor-2 expression in IgA nephropathy: a potential role in the pathogenesis of interstitial fibrosis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Role of coagulation factor Xa and protease-activated receptor 2 in human mesangial cell proliferation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

High expression of pulmonary proteinase-activated receptor 2 in acute and chronic lung injury in preterm infants

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Comparison of the catabolic effects of fibronectin fragments in human knee and ankle cartilages

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Transcriptional Signature of Epidermal Keratinocytes Subjected toin VitroScratch Wounding Reveals Selective Roles for ERK1/2, p38, and Phosphatidylinositol 3-Kinase Signaling Pathways

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312363

Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis

2 December 2018

1 reference

12 December 2020

Mechanisms of neointima formation and remodeling in the porcine coronary artery

1 reference

12 December 2020

Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets

1 reference

12 December 2020

Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots

1 reference

12 December 2020

Inhibition of myofibroblast apoptosis by transforming growth factor beta(1)

1 reference

12 December 2020

Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries

1 reference

12 December 2020

Redifferentiation of smooth muscle cells after coronary angioplasty determined via myosin heavy chain expression

1 reference

12 December 2020

Role of protease activated receptor-2 expression in renal interstitial fibrosis model in mice

1 reference

12 December 2020

Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2

1 reference

12 December 2020

Protease-activated receptors in vascular biology

1 reference

12 December 2020

Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice

1 reference

12 December 2020

Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion

1 reference

12 December 2020

Diminished induction of skin fibrosis in mice with MCP-1 deficiency

1 reference

12 December 2020

Does IL-6 regulate liver fibrosis/cirrhosis directly and indirectly?

1 reference

12 December 2020

Protease-Activated Receptor-2-Mediated Proliferation and Collagen Production of Rat Pancreatic Stellate Cells

1 reference

12 December 2020

Relation of coronary angioscopic findings at coronary angioplasty to angiographic restenosis

1 reference

12 December 2020

10.2353/AJPATH.2008.070347

Identifiers

DOI

1 reference

16 September 2017

1 reference

16 September 2017

1 reference