Physiological promoters reduce the genotoxic risk of integrating gene vectors (Q40003414)

16 September 2017

Physiological promoters reduce the genotoxic risk of integrating gene vectors (English)

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16 September 2017

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Axel Schambach

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Daniela Zychlinski

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object named as

Daniela Zychlinski

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16 September 2017

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Ute Modlich

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16 September 2017

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Tobias Maetzig

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16 September 2017

Johann Meyer

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16 September 2017

Elke Grassman

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16 September 2017

Anjali Mishra

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16 September 2017

Christopher Baum

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16 September 2017

4 March 2008

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16 September 2017

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16 September 2017

718-725

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16 September 2017

4

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Murine leukemia induced by retroviral gene marking

16 September 2017

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7 January 2021

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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7 January 2021

Genotoxicity of retroviral integration in hematopoietic cells.

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7 January 2021

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

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7 January 2021

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

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7 January 2021

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

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7 January 2021

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

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7 January 2021

Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis

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7 January 2021

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

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7 January 2021

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

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7 January 2021

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

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7 January 2021

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

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7 January 2021

Use of the human elongation factor 1 alpha promoter as a versatile and efficient expression system

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7 January 2021

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

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7 January 2021

In vivo analysis of retroviral enhancer mutations in hematopoietic cells: SP1/EGR1 and ETS/GATA motifs contribute to long terminal repeat specificity

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7 January 2021

The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for P

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7 January 2021

Upstream conserved sequences of mouse leukemia viruses are important for high transgene expression in lymphoid and hematopoietic cells

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7 January 2021

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

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7 January 2021

Hot spots of retroviral integration in human CD34+ hematopoietic cells

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7 January 2021

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

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7 January 2021

Murine retroviral but not human cellular promoters induce in vivo erythroid-specific deregulation that can be partially prevented by insulators.

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7 January 2021

Promoter choice for retroviral vectors: transcriptional strength versus trans-activation potential

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7 January 2021

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector

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7 January 2021

Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

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7 January 2021

A chromatin insulator protects retrovirus vectors from chromosomal position effects

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7 January 2021

The dark side of EGFP: defective polyubiquitination

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7 January 2021

Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

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7 January 2021

Plat-E: an efficient and stable system for transient packaging of retroviruses

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7 January 2021

Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose.

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7 January 2021

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors

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7 January 2021

Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors

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7 January 2021

Identifiers

DOI

10.1038/MT.2008.5

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16 September 2017

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