Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth (Q39951891)

15 September 2017

Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth (English)

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15 September 2017

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Sharon Eisenberg

1

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15 September 2017

Klaudia Giehl

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2

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15 September 2017

Yoav I Henis

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3

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15 September 2017

Marcelo Ehrlich

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4

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15 September 2017

language of work or name

English

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publication date

7 August 2008

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Journal of Biological Chemistry

15 September 2017

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15 September 2017

283

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15 September 2017

27279-27288

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15 September 2017

40

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Ras plasma membrane signalling platforms

15 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Differential activation of the Rac pathway by Ha-Ras and K-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Ras signaling on the Golgi

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Ras proteins: different signals from different locations

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Electrical properties of plasma membrane modulate subcellular distribution of K-Ras.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Receptor activation alters inner surface potential during phagocytosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Lipid posttranslational modifications. Farnesyl transferase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

History of the discovery and clinical introduction of chlorpromazine

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Membrane-bound basic peptides sequester multivalent (PIP2), but not monovalent (PS), acidic lipids

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

PIP(2) and proteins: interactions, organization, and information flow

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Effects of psychotropic drugs on cell proliferation and differentiation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Antitumor potential and possible targets of phenothiazine-related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Dislodgment and accelerated degradation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

FRAP beam-size analysis to measure palmitoylation-dependent membrane association dynamics and microdomain partitioning of Ras proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Role of non-phosphorylated activation loop residues in determining ERK2 dephosphorylation, activity, and subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Reversal of the phenotype by K-rasval12 silencing mediated by adenovirus-delivered siRNA in human pancreatic cancer cell line Panc-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Single-molecule imaging analysis of Ras activation in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Selective amphipathic nature of chlorpromazine binding to plasma membrane bilayers

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804589200

Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

The MAP kinase pathway is required for entry into mitosis and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Membrane-permeable Calmodulin Inhibitors (e.g.W-7/W-13) Bind to Membranes, Changing the Electrostatic Surface Potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

Inhibiting Effect of Chlorpromazine on the Experimental Production of Liver Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804589200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804589200

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15 September 2017

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