Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus (Q39948717)

15 September 2017

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus (English)

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15 September 2017

Marie-Luise Sixt

1

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15 September 2017

Karl Messlinger

series ordinal

2

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15 September 2017

Michael J M Fischer

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3

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15 September 2017

language of work or name

English

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publication date

8 September 2009

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15 September 2017

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15 September 2017

132

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15 September 2017

Pt 11

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15 September 2017

3134-3141

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A capsaicin-receptor homologue with a high threshold for noxious heat

15 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

CGRP antagonists: unravelling the role of CGRP in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

CGRP-receptor antagonists--a fresh approach to migraine therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

CGRP blockers in migraine therapy: where do they act?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Release of sensory neuropeptides from dural venous sinuses of guinea pig

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

CGRP may play a causative role in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Calcitonin gene related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

MAPK signal specificity: the right place at the right time

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

CGRP release and c-fos expression within trigeminal nucleus caudalis of the rat following glyceryltrinitrate infusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Migraine: new molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Alterations in neurokinin A-, substance P- and calcitonin gene-related peptide immunoreactivities in the caudal trigeminal nucleus of the rat following electrical stimulation of the trigeminal ganglion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

Ethical guidelines for investigations of experimental pain in conscious animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP168

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWP168

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15 September 2017

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