Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. (Q39941671)

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scientific article published on 18 March 2008

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English	Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.	scientific article published on 18 March 2008

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scholarly article

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4 January 2020

Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs (English)

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author name string

T T Chowdhury

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S Arghandawi

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J Brand

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O O Akanji

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D L Bader

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D M Salter

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18 March 2008

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Arthritis Research and Therapy

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2

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R35

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https://scigraph.springernature.com/pub.10.1186/ar2389

0 references

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes.

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22 September 2017

Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair

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22 September 2017

Nitric oxide synthases and osteoarthritis

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22 September 2017

Evidence for JNK-dependent up-regulation of proteoglycan synthesis and for activation of JNK1 following cyclical mechanical stimulation in a human chondrocyte culture model

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22 September 2017

Quantification of mRNA using real-time RT-PCR

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22 September 2017

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis

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Efficacy and safety of hyaluronan treatment in combination therapy with home exercise for knee osteoarthritis pain

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22 September 2017

Changing life-styles and osteoarthritis: what is the evidence?

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22 September 2017

Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes

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22 September 2017

The role of mechanical loading in the onset and progression of osteoarthritis

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22 September 2017

Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

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22 September 2017

Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals

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22 September 2017

Protein kinases in chondrocyte signaling and osteoarthritis.

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22 September 2017

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.

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22 September 2017

The role of biomechanics and inflammation in cartilage injury and repair.

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22 September 2017

Integrin-dependent signal cascades in chondrocyte mechanotransduction

1 reference

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22 September 2017

Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP

1 reference

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22 September 2017

Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage

1 reference

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22 September 2017

Signal transduction by mechanical strain in chondrocytes

1 reference

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22 September 2017

Response of joint structures to inactivity and to reloading after immobilization

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22 September 2017

The effect of cyclical compressive loading on gene expression in articular cartilage.

1 reference

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22 September 2017

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

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22 September 2017

Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes

1 reference

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22 September 2017

Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

22 September 2017

Nitric oxide in osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

22 September 2017

The role of nitric oxide in articular cartilage damage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

22 September 2017

Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites

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22 September 2017

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

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22 September 2017

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

22 September 2017

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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22 September 2017

Nitric oxide and cartilage metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

25 September 2017

Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade

1 reference

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17 June 2018

Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Biomechanical signals exert sustained attenuation of proinflammatory gene induction in articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Intermittent compressive strain may reduce aggrecanase expression in cartilage: a study of chondrocytes in agarose gel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Influence of oxygen tension on nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Microenvironment regulation of extracellular signal-regulated kinase activity in chondrocytes: effects of culture configuration, interleukin-1, and compressive stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Role of nitric oxide in the activation of NF-kappaB, AP-1 and NOS II expression in articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

17 June 2018

Oxygen, nitric oxide and articular cartilage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Effect of hypoxia and reoxygenation on gene expression and response to interleukin-1 in cultured articular chondrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

A role for the interleukin-1 receptor in the pathway linking static mechanical compression to decreased proteoglycan synthesis in surface articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453754

20 August 2018

The effects of IL-1 on mitogen-activated protein kinases in rabbit articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of static and intermittent compression on nitric oxide production in articular cartilage explants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18348730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348730%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348730%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348730%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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