Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor. (Q39937019)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18809686%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor (English)

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14 January 2020

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2

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14 January 2020

Simon Murray

4

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14 January 2020

author name string

Jordan M Fletcher

1

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14 January 2020

Richard A Zwar

3

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14 January 2020

Paul D O'Leary

5

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14 January 2020

Richard A Hughes

6

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14 January 2020

language of work or name

English

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publication date

22 September 2008

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Journal of Biological Chemistry

14 January 2020

published in

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14 January 2020

volume

283

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14 January 2020

issue

48

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14 January 2020

page(s)

33375-33383

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Structure of nerve growth factor complexed with the shared neurotrophin receptor p75

14 January 2020

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Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

22 September 2017

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22 September 2017

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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

22 September 2017

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Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo.

22 September 2017

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Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures

22 September 2017

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The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site

22 September 2017

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22 September 2017

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

22 September 2017

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Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors

22 September 2017

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Torsion angle dynamics for NMR structure calculation with the new program DYANA

22 September 2017

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An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

22 September 2017

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Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.

22 September 2017

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Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer

22 September 2017

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Sensory neurons in culture: changing requirements for survival factors during embryonic development

22 September 2017

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Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering

22 September 2017

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Cell death during development of the nervous system

22 September 2017

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New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor

22 September 2017

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Substance P: In vitro inactivation by rat brain fractions and human plasma

22 September 2017

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Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview

22 September 2017

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Neurotrophic factors and amyotrophic lateral sclerosis

25 September 2017

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Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

25 September 2017

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Structure-activity relationships of conformationally constrained peptide analogues of loop 2 of brain-derived neurotrophic factor.

25 September 2017

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17 June 2018

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Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

17 June 2018

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17 June 2018

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Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour

20 August 2018

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Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

20 August 2018

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Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action

20 August 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M802789200

The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress

21 January 2018

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The Conformation ofcyclo(−d-Pro−Ala4−) as a Model for Cyclic Pentapeptides of thedL4Type

4 November 2018

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Neurotrophic factors in Alzheimer's and Parkinson's disease brain

21 January 2018

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12 December 2020

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

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12 December 2020

Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination

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12 December 2020

Conformational templates for rational drug design: flexibility of cyclo(D-Pro1-Ala2-Ala3-Ala4-Ala5) in DMSO solution

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12 December 2020

Identifiers

DOI

10.1074/JBC.M802789200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18809686%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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14 January 2020

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