Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. (Q39904004)

15 September 2017

Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. (English)

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amyotrophic lateral sclerosis

15 September 2017

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Yang Liu

1

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15 September 2017

Wenlin Hao

2

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15 September 2017

Alik Dawson

3

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15 September 2017

Shirong Liu

4

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15 September 2017

Klaus Fassbender

5

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15 September 2017

language of work or name

English

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publication date

17 December 2008

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Journal of Biological Chemistry

15 September 2017

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15 September 2017

284

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15 September 2017

3691-3699

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15 September 2017

6

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

15 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804446200

Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Broad expression of Toll-like receptors in the human central nervous system

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804446200

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804446200

Toll-like receptors: critical proteins linking innate and acquired immunity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804446200

Role of TLR-2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

The LPS receptor (CD14) links innate immunity with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Purification of ADAM 10 from bovine spleen as a TNFalpha convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Redox modifier genes in amyotrophic lateral sclerosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Neuropoietic cytokines in the hematopoietic fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

NOX enzymes and the biology of reactive oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

Vitamin E intake and risk of amyotrophic lateral sclerosis

21 January 2018

1 reference

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Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804446200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804446200

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15 September 2017

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