The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts (Q39804637)

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English	The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts	scientific article

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts (English)

1 reference

Europe PubMed Central

14 September 2017

apoptotic process

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acute promyelocytic leukemia

1 reference

based on heuristic

inferred from title

1

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Europe PubMed Central

14 September 2017

author name string

F Grignani

2

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Europe PubMed Central

14 September 2017

P Samoggia

3

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Europe PubMed Central

14 September 2017

C Zanetti

4

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Europe PubMed Central

14 September 2017

R Riccioni

5

1 reference

Europe PubMed Central

14 September 2017

F Lo Coco

6

1 reference

Europe PubMed Central

14 September 2017

D Diverio

7

1 reference

Europe PubMed Central

14 September 2017

N Felli

8

1 reference

Europe PubMed Central

14 September 2017

C G Passerini

9

1 reference

Europe PubMed Central

14 September 2017

M Grell

10

1 reference

Europe PubMed Central

14 September 2017

P G Pelicci

11

1 reference

Europe PubMed Central

14 September 2017

C Peschle

12

1 reference

Europe PubMed Central

14 September 2017

language of work or name

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publication date

1 May 1998

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Europe PubMed Central

14 September 2017

Journal of Clinical Investigation

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Europe PubMed Central

14 September 2017

101

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Europe PubMed Central

14 September 2017

10

1 reference

Europe PubMed Central

14 September 2017

2278-2289

1 reference

Europe PubMed Central

14 September 2017

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Acute promyelocytic leukemia: from genetics to treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Differential expression and functional role of GATA-2, NF-E2, and GATA-1 in normal adult hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Identification of a receptor for the morphogen retinoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

A human retinoic acid receptor which belongs to the family of nuclear receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

22 September 2017

Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

Retinoid differentiation therapy in promyelocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

Biology and treatment of acute promyelocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

All-trans retinoic acid and induction of apoptosis in acute promyelocytic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

PML/RAR alpha+ U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

25 September 2017

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Differences in cell cycle characteristics among patients with acute nonlymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

In vitro action of tumor necrosis factor on myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

15 June 2018

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

20 August 2018

TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

20 August 2018

Evidence that eosinophils catalyze the bromide-dependent decarboxylation of amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508816

20 August 2018

Potentiation of early hematopoiesis by tumor necrosis factor-alpha is followed by inhibition of granulopoietic differentiation and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytostatic and cytotoxic activity of tumor necrosis factor on human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of tumor necrosis factor-alpha by fresh human acute nonlymphoblastic leukemic cells: role in the disappearance of normal CFU-GM progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression of transforming growth factor-beta long cell cycle times and a unique clustering of S-phase cells in patients with acute promyelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute promyelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor receptor expression and signal transduction in HIV-1-infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the 75 kD- and 55 kD-receptors in tumour necrosis factor mediated cytotoxicity and its regulation by dexamethasone and by 1,25-dihydroxyvitamin D3 in U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic growth factor expression and ATRA sensitivity in acute promyelocytic blast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/9593784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI1332

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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