Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). (Q39802745)

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English	Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).	scientific article

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Europe PubMed Central

14 September 2017

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). (English)

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Europe PubMed Central

14 September 2017

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M Brosch

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I Bauer

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14 September 2017

C Schafmayer

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J Tepel

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14 September 2017

S Sebens Müerköster

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14 September 2017

C Röder

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14 September 2017

H Kalthoff

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14 September 2017

M P Moyer

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U R Fölsch

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H Schäfer

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7 September 2009

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28

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3983-3996

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45

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https://scigraph.springernature.com/pub.10.1038/onc.2009.264

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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The development of proteasome inhibitors as anticancer drugs

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The proteasome: a novel target for cancer chemotherapy

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The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death

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Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2.

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The proteasome: paradigm of a self-compartmentalizing protease

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Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue

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Neutralization of complement regulatory proteins CD55 and CD59 augments therapeutic effect of herceptin against lung carcinoma cells.

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Gene expression profiling of NRF2-mediated protection against oxidative injury

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Emerging roles of ubiquitin in transcription regulation

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Structure and functions of the 20S and 26S proteasomes

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Role of proteasomes in disease

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The ubiquitin-proteasome system and cancer

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TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

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Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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Protein degradation and protection against misfolded or damaged proteins

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Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules

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The proteasome is involved in determining differential utilization of double-strand break repair pathways

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

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The ubiquitin system

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Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

1 reference

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

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31 March 2020

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

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31 March 2020

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

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NF-kappaB in cancer: from innocent bystander to major culprit

1 reference

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Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin

1 reference

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Differential expression of the antioxidant response element within the hNQO1 promoter in NSCLC versus SCLC

1 reference

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Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

1 reference

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Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway

1 reference

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Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

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Dual roles of Nrf2 in cancer

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Multiple associated proteins regulate proteasome structure and function

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NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.264

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ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.264

31 March 2020

Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome

1 reference

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31 March 2020

The ubiquitin-proteasome pathway and its role in cancer

1 reference

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31 March 2020

The role of the ubiquitin/proteasome system in cellular responses to radiation

1 reference

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NCM460, a normal human colon mucosal epithelial cell line

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Molecular mechanisms of proteasome assembly

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31 March 2020

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

1 reference

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31 March 2020

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

1 reference

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31 March 2020

The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer

1 reference

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Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment

1 reference

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Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

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Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models

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The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma

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Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer

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Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

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The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition

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Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

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Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

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ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

1 reference

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Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

1 reference

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Caspase activation inhibits proteasome function during apoptosis

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E3 ubiquitin ligases as cancer targets and biomarkers

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CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

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The neuronal ubiquitin-proteasome system: murine models and their neurological phenotype.

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

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Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

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Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation

1 reference

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31 March 2020

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit

1 reference

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

1 reference

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Emerging roles for ubiquitin and protein degradation in neuronal function

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Regulation of apoptosis proteins in cancer cells by ubiquitin

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31 March 2020

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10.1038/ONC.2009.264

1 reference

Europe PubMed Central

14 September 2017

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Europe PubMed Central

14 September 2017

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