Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation. (Q39791417)

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scientific article published on October 1997

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English	Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.	scientific article published on October 1997

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scholarly article

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6 November 2019

Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation (English)

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6 November 2019

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author name string

Fischer M

1

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Klein U

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1 October 1997

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6 November 2019

Journal of Clinical Investigation

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1667-1676

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6 November 2019

Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries

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Receptor editing: an approach by autoreactive B cells to escape tolerance

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Expressed human immunoglobulin kappa genes and their hypermutation

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Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression

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Switch recombination in normal IgA1+ B lymphocytes

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Analysis of somatic mutation in five B cell subsets of human tonsil

1 reference

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Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors

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Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia

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Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals

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B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes

1 reference

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22 September 2017

Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells

1 reference

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

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Evidence that the V kappa III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal

1 reference

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B-1 cellular origin and VH segment structure of IgG, IgA, and IgM anti-DNA autoantibodies in patients with systemic lupus erythematosus

1 reference

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22 September 2017

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice

1 reference

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22 September 2017

Evolution of human immunoglobulin kappa J region genes

1 reference

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22 September 2017

Specificity of recombination of H and L chains from human gamma-G-myeloma proteins

1 reference

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22 September 2017

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells

1 reference

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22 September 2017

Evolutionary and somatic selection of the antibody repertoire in the mouse.

1 reference

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22 September 2017

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy

1 reference

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22 September 2017

1 reference

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22 September 2017

Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes

1 reference

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22 September 2017

Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 mice

1 reference

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22 September 2017

Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life

1 reference

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22 September 2017

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

1 reference

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22 September 2017

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

22 September 2017

Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

22 September 2017

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

22 September 2017

The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

22 September 2017

Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia

1 reference

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22 September 2017

In situ studies of the germinal center reaction

1 reference

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25 September 2017

The variable genes of the human immunoglobulin kappa locus

1 reference

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25 September 2017

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections

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25 September 2017

Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment

1 reference

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25 September 2017

Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers

1 reference

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25 September 2017

B-1 cells: unique origins and functions.

1 reference

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25 September 2017

Intraclonal generation of antibody mutants in germinal centres

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25 September 2017

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features

1 reference

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15 June 2018

High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia.

1 reference

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15 June 2018

Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enh

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

15 June 2018

V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

15 June 2018

A directory of human germ-line V kappa segments reveals a strong bias in their usage

1 reference

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15 June 2018

Comparable profiles of the immunoglobulin heavy chain complementarity determining region (CDR)-3 in CD5+ and CD5- human cord blood B lymphocytes.

1 reference

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15 June 2018

Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.

1 reference

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15 June 2018

Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

15 June 2018

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

1 reference

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Antigenic phenotype and functional characterization of human tonsil B cells.

1 reference

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Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal idiotypic antibody reveals extensive somatic variability suggestive of an antigen-driven immune response

1 reference

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Maturation of the immune response in germinal centers

1 reference

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15 June 2018

Antibody specificity and immunoglobulin VH utilization of human monoclonal CD5+ B cell lines

1 reference

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15 June 2018

Ongoing V kappa-J kappa recombination after formation of a productive V kappa-J kappa coding joint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

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Evidence for a large compartment of IgM-expressing memory B cells in humans.

1 reference

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20 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

De novo development and self-replenishment of B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508349

20 August 2018

Identification of two distinct CD5- B cell subsets from human tonsils with different responses to CD40 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic and functional characterization of human Leu1 (CD5) B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The frequency of multiple recombination events occurring at the human Ig kappa L chain locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phenotypic study of B lymphocyte subpopulations in human bone marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cells of chronic lymphatic leukemia express V genes in unmutated form

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-chronic lymphocytic leukemia: a malignancy of anti-self B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ontogeny and functional characteristics of human B-1 (CD5+ B) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9312164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119691

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9312164%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9312164%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9312164%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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