Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. (Q39777007)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901272%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis (English)

1 reference

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12 February 2020

0 references

6

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12 February 2020

author name string

Ying Geng

1

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12 February 2020

K C Walls

2

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12 February 2020

Arindam P Ghosh

3

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12 February 2020

Rizwan S Akhtar

4

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12 February 2020

Barbara J Klocke

5

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12 February 2020

publication date

9 November 2009

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Journal of Histochemistry and Cytochemistry

12 February 2020

published in

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12 February 2020

volume

58

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12 February 2020

issue

3

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12 February 2020

page(s)

265-275

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Classic and novel roles of p53: prospects for anticancer therapy

12 February 2020

cites work

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Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death.

22 September 2017

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Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

22 September 2017

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p53 is cleaved by caspases generating fragments localizing to mitochondria

22 September 2017

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

22 September 2017

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Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation

22 September 2017

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22 September 2017

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PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

22 September 2017

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Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

22 September 2017

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Perinatal hypoxia/ischemia damages and depletes progenitors from the mouse subventricular zone.

22 September 2017

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Role of programmed cell death in normal neuronal development and function

22 September 2017

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

22 September 2017

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

22 September 2017

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p53-dependent cell death signaling in neurons

22 September 2017

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Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

22 September 2017

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Post-translational modifications and activation of p53 by genotoxic stresses

22 September 2017

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Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

22 September 2017

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New prospects for human stem-cell therapy in the nervous system

22 September 2017

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Getting across the nuclear pore complex

22 September 2017

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

22 September 2017

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

22 September 2017

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

22 September 2017

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Long-term evolution and functional diversification in the members of the nucleophosmin/nucleoplasmin family of nuclear chaperones

25 September 2017

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Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons

17 June 2018

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17 June 2018

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Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons.

17 June 2018

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20 August 2018

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Neural precursor cells possess multiple p53-dependent apoptotic pathways

20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma.

20 August 2018

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High-frequency developmental abnormalities in p53-deficient mice.

20 August 2018

1 reference

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Pharmacological rescue of mutant p53 conformation and function

20 August 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19901272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A subset of p53-deficient embryos exhibit exencephaly

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19901272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1369/JHC.2009.954024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901272%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901272%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference