Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs (Q39776959)

14 September 2017

Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs (English)

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14 September 2017

2

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14 September 2017

Thomas A White

1

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14 September 2017

1 January 2004

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Comparative and Functional Genomics

14 September 2017

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14 September 2017

5

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14 September 2017

304-327

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14 September 2017

4

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Creative Commons Attribution 3.0 Unported

14 September 2017

start time

1 January 2004

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Detection in Escherichia coli of the genes encoding the major virulence factors, the genes defining the O157:H7 serotype, and components of the type 2 Shiga toxin family by multiplex PCR.

22 September 2017

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New (and not so new) antibacterial targets - from where and when will the novel drugs come?

22 September 2017

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Two-component and phosphorelay signal-transduction systems as therapeutic targets

22 September 2017

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Bacillus anthracis genetics and virulence gene regulation

22 September 2017

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22 September 2017

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Virulence as a target for antimicrobial chemotherapy

22 September 2017

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Streptococcus pneumoniae as a genomics platform for broad-spectrum antibiotic discovery

22 September 2017

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Genomics strategies for antifungal drug discovery--from gene discovery to compound screening

22 September 2017

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Microbial genomics and novel antibiotic discovery: new technology to search for new drugs

22 September 2017

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Genomics in anti-infective drug discovery--getting to endgame

22 September 2017

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Genomics and the prospects for the discovery of new targets for antibacterial and antifungal agents

22 September 2017

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The role of genomics in the discovery of novel targets for antibiotic therapy

22 September 2017

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Exploiting current understanding of antibiotic action for discovery of new drugs.

22 September 2017

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UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug

22 September 2017

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A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

22 September 2017

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Delivering novel targets and antibiotics from genomics

22 September 2017

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Streptomycin revisited: molecular action in the microbial cell

22 September 2017

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The impact of genomics and related technologies on the search for new antibiotics

22 September 2017

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MEGA2: molecular evolutionary genetics analysis software

22 September 2017

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Exploiting genomics to discover new antibiotics

22 September 2017

1 reference

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Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.

22 September 2017

1 reference

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The role of genomics in antibacterial target discovery

22 September 2017

1 reference

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Machine learning for science: state of the art and future prospects

22 September 2017

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Novel type of fimbriae encoded by the large plasmid of sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H(-)

22 September 2017

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Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery

22 September 2017

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

22 September 2017

1 reference

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In silico research in drug discovery

22 September 2017

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Functional genomics of Neisseria meningitidis pathogenesis

22 September 2017

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Life on the inside: probing mycobacterium tuberculosis gene expression during infection

22 September 2017

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The impact of bacterial genomics on antibacterial discovery.

22 September 2017

1 reference

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New antibiotic discovery, novel screens, novel targets and impact of microbial genomics

22 September 2017

1 reference

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The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

22 September 2017

1 reference

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The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Translation initiation factor IF1 is essential for cell viability in Escherichia coli

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Basic local alignment search tool

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Strobilurin D and strobilurin F: two new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotics from Cyphellopsis anomala (1).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

How antibiotics cause antibiotic resistance

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Tetracyclines: antibiotic action, uptake, and resistance mechanisms

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Inactivation of antibiotics and the dissemination of resistance genes

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23S rRNA.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Molecular imaging of drug-modulated protein-protein interactions in living subjects

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Detection of type III secretion genes as a general indicator of bacterial virulence

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Genomic profiling of drug sensitivities via induced haploinsufficiency.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

The epidemiology of antimicrobial resistance in hospital acquired infections: problems and possible solutions

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Detection of enterohemorrhagic Escherichia coli O157:H7 by using a multiplex real-time PCR assay for genes encoding intimin and Shiga toxins

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Knockouts model the 100 best-selling drugs--will they model the next 100?

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Interaction of translation initiation factor IF1 with the E. coli ribosomal A site.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447455

Phosphinate Inhibitors of the D-Glutamic Acid-Adding Enzyme of Peptidoglycan Biosynthesis

20 August 2018

1 reference

12 December 2020

Novel approaches to the discovery of antimicrobial agents

1 reference

12 December 2020

Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells

1 reference

12 December 2020

Computer-aided target selection-prioritizing targets for antifungal drug discovery

1 reference

12 December 2020

Control of virulence gene expression in Bacillus anthracis

1 reference

12 December 2020

Translational initiation factors IF-1 and eIF-2α share an RNA-binding motif with prokaryotic ribosomal protein S1 and polynucleotide phosphorylase

1 reference

12 December 2020

Identifiers

DOI

10.1002/CFG.411

1 reference

14 September 2017

1 reference

14 September 2017

1 reference

PMCID

2447455