Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. (Q39776848)

14 September 2017

Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. (English)

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14 September 2017

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Emmanuelle Bazin

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14 September 2017

Annick Mourot

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2

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14 September 2017

Andrew R Humpage

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3

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14 September 2017

Valérie Fessard

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4

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14 September 2017

1 April 2010

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Environmental and Molecular Mutagenesis

14 September 2017

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14 September 2017

51

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14 September 2017

3

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14 September 2017

251-259

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The in vitro micronucleus technique

14 September 2017

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Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin

21 January 2018

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Strategy for genotoxicity testing--metabolic considerations

21 January 2018

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

21 January 2018

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7 January 2021

Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo

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7 January 2021

Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins

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7 January 2021

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

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7 January 2021

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

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7 January 2021

Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco-2 cells. Status of the pRb1 and pRb2 tumor suppressor gene products.

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7 January 2021

Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells

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7 January 2021

Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin

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7 January 2021

Cyanobacterial (blue-green algal) toxins in water supplies: Cylindrospermopsins.

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7 January 2021

Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells.

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7 January 2021

Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes

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7 January 2021

Cytotoxicity screening for the cyanobacterial toxin cylindrospermopsin

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7 January 2021

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

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7 January 2021

Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method

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7 January 2021

Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress

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7 January 2021

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

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7 January 2021

No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation.

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7 January 2021

FIRST REPORT OF THE CYANOTOXINS CYLINDROSPERMOPSIN AND DEOXYCYLINDROSPERMOPSIN FROM RAPHIDIOPSIS CURVATA (CYANOBACTERIA)

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7 January 2021

Studies of the comparative in vitro toxicology of the cyanobacterial metabolite deoxycylindrospermopsin.

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7 January 2021

Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse

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7 January 2021

Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii

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7 January 2021

Inhibition and induction of human cytochrome P450 enzymes: current status

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7 January 2021

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines

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7 January 2021

First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes

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7 January 2021

The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes

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7 January 2021

Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes

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7 January 2021

Identification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskii

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7 January 2021

Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity

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7 January 2021

Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin

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7 January 2021

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology

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7 January 2021

First observation of cylindrospermopsin in Anabaena lapponica isolated from the boreal environment (Finland)

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7 January 2021

Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible

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7 January 2021

Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans

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7 January 2021

Identifiers

DOI

10.1002/EM.20539

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14 September 2017

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