Axonal transport defects are a common phenotype in Drosophila models of ALS. (Q39774347)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056981%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Axonal transport defects are a common phenotype in Drosophila models of ALS (English)

1 reference

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amyotrophic lateral sclerosis

31 March 2020

main subject

Drosophila

0 references

1 reference

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3

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31 March 2020

author name string

Katie R Baldwin

series ordinal

1

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31 March 2020

Vinay K Godena

series ordinal

2

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31 March 2020

Alexander J Whitworth

series ordinal

4

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31 March 2020

publication date

7 April 2016

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31 March 2020

published in

Human Molecular Genetics

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31 March 2020

volume

25

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31 March 2020

issue

12

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31 March 2020

page(s)

2378-2392

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describes a project that uses

31 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5181624/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

22 September 2017

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Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

22 September 2017

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The changing scene of amyotrophic lateral sclerosis

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The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

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Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

22 September 2017

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22 September 2017

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The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

1 reference

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Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

22 September 2017

1 reference

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Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

22 September 2017

1 reference

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Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.

22 September 2017

1 reference

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Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

22 September 2017

1 reference

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Control of mitochondrial transport and localization in neurons.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

TDP-43 is recruited to stress granules in conditions of oxidative insult.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Structural determinants of the cellular localization and shuttling of TDP-43.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways.

22 September 2017

1 reference

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Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Imaging axonal transport of mitochondria

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181624

20 August 2018

Identifiers

DOI

10.1093/HMG/DDW105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056981%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056981%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference