Inefficacy interim monitoring procedures in randomized clinical trials: the need to report (Q39772400)

14 September 2017

Inefficacy interim monitoring procedures in randomized clinical trials: the need to report (English)

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14 September 2017

2

Boris Freidlin

1 reference

14 September 2017

Edward L Korn

1

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14 September 2017

1 March 2011

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American Journal of Bioethics

14 September 2017

9

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based on heuristic

inferred from page(s)

published in

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14 September 2017

11

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14 September 2017

2-10

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14 September 2017

3

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The agonising negative trend in monitoring of clinical trials

14 September 2017

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Early stopping of a clinical trial when there is evidence of no treatment benefit: protocol B-14 of the National Surgical Adjuvant Breast and Bowel Project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Monitoring for lack of benefit: a critical component of a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A general inefficacy interim monitoring rule for randomized clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Randomized clinical trials with biomarkers: design issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Intensive versus conventional glucose control in critically ill patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

When to stop a clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

The futility index. An approach to the cost-effective termination of randomized clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Tubular diskectomy vs conventional microdiskectomy for sciatica: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomized trial of doxycycline for Mansonella perstans infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Injectable collagenase clostridium histolyticum for Dupuytren's contracture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Stepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study: design and practical implications of an intervention for comorbid pain and depression

21 January 2018

1 reference

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Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Radiofrequency ablation in Barrett's esophagus with dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Fractional flow reserve versus angiography for guiding percutaneous coronary intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Routine early angioplasty after fibrinolysis for acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Rationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Preemptive use of high-dose fluticasone for virus-induced wheezing in young children

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Valsartan for prevention of recurrent atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

The Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial: study design and rationale

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Machine perfusion or cold storage in deceased-donor kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Diacetylmorphine versus methadone for the treatment of opioid addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Oral prednisolone for preschool children with acute virus-induced wheezing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Efficacy of esomeprazole for treatment of poorly controlled asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Rationale and design of Ferinject assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Ferric carboxymaltose in patients with heart failure and iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Moderate hypothermia to treat perinatal asphyxial encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

High-flow oxygen for treatment of cluster headache: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Antibiotic prophylaxis and recurrent urinary tract infection in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

High-dose daunorubicin in older patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

ACE-I and ARBs in early diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Renal and retinal effects of enalapril and losartan in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Early versus Delayed Invasive Intervention in Acute Coronary Syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Immediate vs delayed intervention for acute coronary syndromes: a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Fluvastatin and perioperative events in patients undergoing vascular surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Biventricular pacing in patients with bradycardia and normal ejection fraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of clopidogrel added to aspirin in patients with atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Management of elderly patients with congestive heart failure--design of the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of dipyridamole plus aspirin on hemodialysis graft patency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Strict blood-pressure control and progression of renal failure in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Rosuvastatin and cardiovascular events in patients undergoing hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of rosuvastatin on outcomes in chronic haemodialysis patients - design and rationale of the AURORA study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Coronary bypass surgery with or without surgical ventricular reconstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomized trial of vertebroplasty for osteoporotic spinal fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Cardiac-resynchronization therapy for the prevention of heart-failure events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Intensity of continuous renal-replacement therapy in critically ill patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Extended-release niacin or ezetimibe and carotid intima-media thickness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Intravenous platelet blockade with cangrelor during PCI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Anthracycline dose intensification in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Platelet inhibition with cangrelor in patients undergoing PCI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Interleukin-2 therapy in patients with HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Glucose control and vascular complications in veterans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Early versus delayed, provisional eptifibatide in acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) tria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A multicenter, randomized trial of treatment for mild gestational diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Epinephrine and dexamethasone in children with bronchiolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Denosumab in men receiving androgen-deprivation therapy for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Advanced heart failure treated with continuous-flow left ventricular assist device.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Ticagrelor versus clopidogrel in patients with acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomized trial of therapies for type 2 diabetes and coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Preoperative staging of lung cancer with combined PET-CT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Endocrine therapy plus zoledronic acid in premenopausal breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Effect of dronedarone on cardiovascular events in atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

A randomised controlled trial to assess the efficacy of Laparoscopic Uterosacral Nerve Ablation (LUNA) in the treatment of chronic pelvic pain: The trial protocol [ISRCTN41196151]

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Rationale and design of the GISSI-Atrial Fibrillation trial: a randomized, prospective, multicentre study on the use of valsartan, an angiotensin II AT1-receptor blocker, in the prevention of atrial fibrillation recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

Defibrillator implantation early after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15265161.2010.546471

10.1080/15265161.2010.546471

21 January 2018

Identifiers

DOI

1 reference

14 September 2017

1 reference

PubMed ID

21400374