The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway (Q39771227)

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English	The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway	scientific article

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14 September 2017

The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway (English)

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14 September 2017

author name string

Zhiwen Zeng

1

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6 June 2020

Xue Wang

2

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6 June 2020

Sanjeev K Bhardwaj

3

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6 June 2020

Xuanhe Zhou

4

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6 June 2020

Lalit K Srivastava

7

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6 June 2020

Wenhua Zheng

8

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publication date

13 May 2016

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14 September 2017

Molecular Neurobiology

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54

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6 June 2020

3395-3406

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5

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6 June 2020

https://scigraph.springernature.com/pub.10.1007/s12035-016-9904-4

0 references

The possible role of the Akt signaling pathway in schizophrenia.

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21 January 2018

Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studies

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21 January 2018

Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis.

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Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells

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21 January 2018

Olanzapine potentiates neuronal survival and neural stem cell differentiation: regulation of endoplasmic reticulum stress response proteins.

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21 January 2018

Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

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21 January 2018

Paliperidone protects SK-N-SH cells against glutamate toxicity via Akt1/GSK3β signaling pathway

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https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+‐induced apoptosis

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https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action

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https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content

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21 January 2018

Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation

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21 January 2018

Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice.

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21 January 2018

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

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21 January 2018

Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses

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21 January 2018

Clozapine and lithium require Caenorhabditis elegans β-arrestin and serum- and glucocorticoid-inducible kinase to affect Daf-16 (FOXO) localization.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans

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21 January 2018

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

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21 January 2018

Stress and anxiety in schizophrenia and depression: glucocorticoids, corticotropin-releasing hormone and synapse regression

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21 January 2018

The stress cascade and schizophrenia: etiology and onset

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Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia

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21 January 2018

Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

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https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons.

1 reference

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21 January 2018

The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Insulin-like growth factor 1 prevents neuronal cell death induced by corticosterone through activation of the PI3k/Akt pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways

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21 January 2018

Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons

1 reference

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21 January 2018

Akt, FoxO and regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

1 reference

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21 January 2018

Akt/GSK3 signaling in the action of psychotropic drugs

1 reference

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21 January 2018

Atypical antipsychotics and suicide in mood and anxiety disorders

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21 January 2018

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

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21 January 2018

Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF receptor.

1 reference

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21 January 2018

The effects of clozapine on the GSK-3-mediated signaling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Antipsychotic drugs activate the C. elegans akt pathway via the DAF-2 insulin/IGF-1 receptor

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

"Sly as a FOXO": new paths with Forkhead signaling in the brain

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-9904-4

21 January 2018

Rit subfamily small GTPases: regulators in neuronal differentiation and survival

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21 January 2018

FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells

1 reference

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21 January 2018

Clinical and neurocognitive effects of clozapine and risperidone in treatment-refractory schizophrenic patients: a prospective study.

1 reference

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Antisuicide properties of psychotropic drugs: a critical review

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1 reference

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Clozapine versus typical neuroleptic medication for schizophrenia

1 reference

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A randomized controlled trial of olanzapine versus haloperidol in the treatment of primary negative symptoms and neurocognitive deficits in schizophrenia.

1 reference

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Identification of functional glucocorticoid response elements in the mouse FoxO1 promoter

1 reference

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The effects of clozapine on negative symptoms in patients with schizophrenia with minimal positive symptoms

1 reference

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inferred from PubMed ID database lookup

Clozapine induction of ERK1/2 cell signalling via the EGF receptor in mouse prefrontal cortex and striatum is distinct from other antipsychotic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27173157

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27173157

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Identifiers

10.1007/S12035-016-9904-4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27173157%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27173157%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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