PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element. (Q39766229)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19966852%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element (English)

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13 February 2020

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1

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13 February 2020

author name string

Ch Neururer

2

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13 February 2020

A Steege

3

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13 February 2020

S Vallabhapurapu

4

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13 February 2020

T Pabst

5

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13 February 2020

B U Mueller

6

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13 February 2020

language of work or name

English

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publication date

7 December 2009

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13 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19966852%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

29

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13 February 2020

issue

7

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13 February 2020

page(s)

1062-1072

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https://scigraph.springernature.com/pub.10.1038/onc.2009.371

13 February 2020

exact match

0 references

cites work

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PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

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C/EBPalpha induces PU.1 and interacts with AP-1 and NF-kappaB to regulate myeloid development

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Structure of NF-kappa B p50 homodimer bound to a kappa B site

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

21 January 2018

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The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.

21 January 2018

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The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

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Long-range control of gene expression: emerging mechanisms and disruption in disease

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Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

21 January 2018

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Cross-talk between regulators of myeloid development: C/EBPalpha binds and activates the promoter of the PU.1 gene

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Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation

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Complex controls: the role of alternative promoters in mammalian genomes

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Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

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ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

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Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis

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Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

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Potential autoregulation of transcription factor PU.1 by an upstream regulatory element

21 January 2018

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CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.

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Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

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A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

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Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction

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Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia

21 January 2018

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NF-kappa B binding mechanism: a nuclear magnetic resonance and modeling study of a GGG --> CTC mutation

21 January 2018

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Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

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21 January 2018

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C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

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PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

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