TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype (Q39739202)

14 September 2017

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype (English)

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Peter Nürnberg

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Xin Wang

5

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Evelien Dekker

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object named as

Evelien Dekker

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14 September 2017

15

Hans Clevers

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14 September 2017

Evelyn Fessler

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14 September 2017

Sander R van Hooff

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Janneke F Linnekamp

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Marnix Jansen

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Felipe De Sousa E Melo

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Pramudita R Prasetyanti

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Joep Eg IJspeert

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Marek Franitza

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Carel Jm van Noesel

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Jan Paul Medema

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23 May 2016

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EMBO Molecular Medicine

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745-760

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describes a project that uses

14 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4931289/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4931289

inferred from PubMed Central ID database lookup

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CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

14 September 2017

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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

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Serrated neoplasia-role in colorectal carcinogenesis and clinical implications

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14 September 2017

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14 September 2017

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Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon

14 September 2017

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14 September 2017

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Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

14 September 2017

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Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer

14 September 2017

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14 September 2017

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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

14 September 2017

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A colorectal cancer classification system that associates cellular phenotype and responses to therapy

14 September 2017

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

14 September 2017

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14 September 2017

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Multiplex genome engineering using CRISPR/Cas systems

14 September 2017

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Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

14 September 2017

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Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression

14 September 2017

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MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

14 September 2017

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SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

14 September 2017

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TGFβ signalling in context

14 September 2017

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Comprehensive molecular characterization of human colon and rectal cancer

14 September 2017

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Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior.

14 September 2017

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Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

14 September 2017

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Update on the serrated pathway to colorectal carcinoma

14 September 2017

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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

14 September 2017

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Role of the serrated pathway in colorectal cancer pathogenesis

14 September 2017

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Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes

14 September 2017

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14 September 2017

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TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2

14 September 2017

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14 September 2017

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The epithelial-mesenchymal transition generates cells with properties of stem cells

14 September 2017

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

14 September 2017

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Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

14 September 2017

1 reference

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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

14 September 2017

1 reference

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Adjusting batch effects in microarray expression data using empirical Bayes methods

14 September 2017

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

14 September 2017

1 reference

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BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Frequent CpG island methylation in serrated adenomas of the colorectum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Summaries of Affymetrix GeneChip probe level data

14 September 2017

1 reference

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Epithelial-mesenchymal transitions in tumour progression

14 September 2017

1 reference

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Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

A genetic model for colorectal tumorigenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Sequential cancer mutations in cultured human intestinal stem cells.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4931289

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

20 August 2018

1 reference

12 December 2020

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer

1 reference

12 December 2020

Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer

1 reference

12 December 2020

The evolution of cancer of the colon and rectum

1 reference

12 December 2020

Progression of a sessile serrated adenoma to an early invasive cancer within 8 months

1 reference

12 December 2020

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

1 reference

12 December 2020

Identifiers

DOI

10.15252/EMMM.201606184

1 reference

14 September 2017

1 reference

14 September 2017

1 reference