Thrombopoietin expands hematopoietic stem cells after transplantation (Q39738286)

14 September 2017

Thrombopoietin expands hematopoietic stem cells after transplantation (English)

1 reference

14 September 2017

Norma Fox

1

1 reference

14 September 2017

Greg Priestley

series ordinal

2

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14 September 2017

Thalia Papayannopoulou

series ordinal

3

1 reference

14 September 2017

Kenneth Kaushansky

series ordinal

4

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14 September 2017

language of work or name

English

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publication date

1 August 2002

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Journal of Clinical Investigation

14 September 2017

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14 September 2017

110

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14 September 2017

389-394

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14 September 2017

3

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Molecular cloning and chromosomal localization of the human thrombopoietin gene.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Thrombopoietin: the primary regulator of platelet production.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Thrombopoietin: its biology, purification, and characterization

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Regulators of thrombopoiesis: their biochemistry and physiology

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Homing and trafficking of hemopoietic progenitor cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Role of c-mpl in early hematopoiesis.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151089

Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

20 August 2018

1 reference

12 December 2020

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice

1 reference

12 December 2020

Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation

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12 December 2020

Modulation of platelet activation in vitro by thrombopoietin

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12 December 2020

Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion

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12 December 2020

The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells

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12 December 2020

Bone marrow cell trafficking following intravenous administration

1 reference

12 December 2020

Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis

1 reference

12 December 2020

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1 reference

12 December 2020

Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice

1 reference

12 December 2020

Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin

1 reference

12 December 2020

Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI0215430

1 reference

14 September 2017

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14 September 2017

1 reference