Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. (Q39737543)

14 September 2017

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. (English)

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14 September 2017

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Ariane Chan

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14 September 2017

Peter M Andreae

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2

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14 September 2017

Peter T Northcote

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3

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14 September 2017

John H Miller

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4

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14 September 2017

20 February 2010

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Investigational New Drugs

14 September 2017

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14 September 2017

29

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4

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615-626

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https://scigraph.springernature.com/pub.10.1007/s10637-010-9398-2

14 September 2017

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Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

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A unique mode of microtubule stabilization induced by peloruside A

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Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine

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NMR determination of the bioactive conformation of peloruside A bound to microtubules.

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Structural microtubule cap: stability, catastrophe, rescue, and third state

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Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines

21 January 2018

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Taxol suppresses dynamics of individual microtubules in living human tumor cells

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Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells

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Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity

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Vinblastine suppresses dynamics of individual microtubules in living interphase cells

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Detection of GTP-tubulin conformation in vivo reveals a role for GTP remnants in microtubule rescues.

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Visualization of the dynamic instability of individual microtubules by dark-field microscopy

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Microtubule bundling in cells

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Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity

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12 December 2020

Orientation, assembly, and stability of microtubule bundles induced by a fragment of tau protein

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12 December 2020

Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest

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12 December 2020

Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins

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12 December 2020

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp

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12 December 2020

Microtubule dynamics in vitro are regulated by the tubulin isotype composition

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12 December 2020

Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation

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12 December 2020

10.1007/S10637-010-9398-2

Identifiers

DOI

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14 September 2017

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