Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor (Q39714879)

14 September 2017

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor (English)

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14 September 2017

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4

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14 September 2017

3

H L Ploegh

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14 September 2017

A Rehm

1

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PMCID

145509

14 September 2017

P Stern

series ordinal

2

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PMCID

145509

14 September 2017

language of work or name

English

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publication date

1 April 2001

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14 September 2017

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14 September 2017

20

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14 September 2017

7

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14 September 2017

1573-1582

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The translocon: a dynamic gateway at the ER membrane

14 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Regulation of protein biogenesis at the endoplasmic reticulum membrane

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Crystal structure of the signal sequence binding subunit of the signal recognition particle

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

A mutation downstream from the signal peptidase cleavage site affects cleavage but not membrane insertion of phage coat protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Patterns of amino acids near signal-sequence cleavage sites

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal sequences. The limits of variation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Purification of microsomal signal peptidase as a complex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal peptidases in prokaryotes and eukaryotes--a new protease family

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal peptides: exquisitely designed transport promoters

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Control of expression, glycosylation, and secretion of HIV-1 gp120 by homologous and heterologous signal sequences

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Sequences beyond the cleavage site influence signal peptide function.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145509

Deletion of the propeptide from human preproapolipoprotein A-II redirects cotranslational processing by signal peptidase

17 June 2018

1 reference

12 December 2020

A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

1 reference

12 December 2020

Signal sequence processing in rough microsomes

1 reference

12 December 2020

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

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12 December 2020

The alpha chain of the T cell antigen receptor is degraded in the cytosol

1 reference

12 December 2020

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

12 December 2020

Signal sequences: more than just greasy peptides

1 reference

12 December 2020

Life and death of a signal peptide

1 reference

12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/20.7.1573

1 reference

14 September 2017

1 reference

14 September 2017

1 reference

PMCID

145509