Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit (Q39706350)

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English	Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit	scientific article

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit (English)

1 reference

Europe PubMed Central

14 September 2017

torsades de pointes

1 reference

based on heuristic

inferred from title

author name string

Ingemar Jacobson

1

1 reference

Europe PubMed Central

14 September 2017

Leif Carlsson

2

1 reference

Europe PubMed Central

14 September 2017

Göran Duker

3

1 reference

Europe PubMed Central

14 September 2017

publication date

6 May 2010

1 reference

Europe PubMed Central

14 September 2017

Journal of Pharmacological and Toxicological Methods

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Europe PubMed Central

14 September 2017

63

1 reference

Europe PubMed Central

14 September 2017

40-46

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Europe PubMed Central

14 September 2017

1

1 reference

Europe PubMed Central

14 September 2017

Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential

1 reference

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7 January 2021

The combined ion channel blocker AZD1305 attenuates late Na current and IKr-induced action potential prolongation and repolarization instability

1 reference

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3H-batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: inhibition by the channel blockers tetrodotoxin and saxitoxin.

1 reference

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7 January 2021

The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes

1 reference

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Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo

1 reference

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A high-throughput HERG potassium channel function assay: an old assay with a new look

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Rapid conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009

1 reference

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Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia

1 reference

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Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

1 reference

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Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

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Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

1 reference

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Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.

1 reference

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Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation

1 reference

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RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents

1 reference

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Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD7009

1 reference

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

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Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less

1 reference

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7 January 2021

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

1 reference

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7 January 2021

Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

1 reference

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Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

1 reference

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Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits

1 reference

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7 January 2021

Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits

1 reference

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Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes

1 reference

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7 January 2021

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10.1016/J.VASCN.2010.04.010

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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