Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model. (Q39706220)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27267807%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27267807%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

0 references

1 reference

1 reference

Jesse Gore

1

1 reference

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12 March 2020

Imade E Imasuen-Williams

series ordinal

2

1 reference

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12 March 2020

Abass M Conteh

series ordinal

3

1 reference

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12 March 2020

Monica Cheng

series ordinal

5

1 reference

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12 March 2020

language of work or name

English

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publication date

3 June 2016

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12 March 2020

1 reference

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12 March 2020

volume

379

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12 March 2020

issue

1

1 reference

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12 March 2020

page(s)

143-153

1 reference

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The lymphatic system and pancreatic cancer

12 March 2020

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CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation

14 September 2017

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Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.

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Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis

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TGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin.

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Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin

14 September 2017

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VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model.

14 September 2017

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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

14 September 2017

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Targeting the TGFβ signalling pathway in disease

14 September 2017

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S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

14 September 2017

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

14 September 2017

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14 September 2017

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Lymphangiogenesis and biological behavior in pancreatic carcinoma and other pancreatic tumors

14 September 2017

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The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma

14 September 2017

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A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis

14 September 2017

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14 September 2017

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Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions

14 September 2017

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

14 September 2017

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Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts

14 September 2017

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14 September 2017

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Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells

14 September 2017

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14 September 2017

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Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

14 September 2017

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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

14 September 2017

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Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

14 September 2017

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14 September 2017

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Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread

14 September 2017

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14 September 2017

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20 August 2018

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Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis

14 September 2017

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Pathways for aberrant angiogenesis in pancreatic cancer

14 September 2017

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Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis

14 September 2017

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Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

14 September 2017

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Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.

14 September 2017

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Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis

14 September 2017

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VEGF-RII influences the prognosis of pancreatic cancer

14 September 2017

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Epithelial Cell Cultures From Normal and Cancerous Human Tissues2

14 September 2017

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Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation.

14 September 2017

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Effect of CCR7, CXCR4 and VEGF-C on the lymph node metastasis of human pancreatic ductal adenocarcinoma

20 August 2018

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20 August 2018

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Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study

20 August 2018

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Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease

20 August 2018

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Chemokine receptor CCR7 expression correlates with lymph node metastasis in pancreatic cancer

20 August 2018

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20 August 2018

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20 August 2018

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12 December 2020

M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer

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Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer

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12 December 2020

Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma

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Molecular pathogenesis of pancreatic cancer

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Expression of vascular endothelial growth factors-C and -D correlate with evidence of lymphangiogenesis and angiogenesis in pancreatic adenocarcinoma

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Amphiregulin is a potent mitogen in human pancreatic-cancer cells - correlation with patient survival

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Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer

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10.1016/J.CANLET.2016.05.037

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27267807%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27267807%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

27267807

1 reference