Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke? (Q39698015)

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English	Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?	scientific article

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke? (English)

1 reference

Europe PubMed Central

14 September 2017

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apoptotic process

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author name string

Waltraud Pfeilschifter

1

1 reference

Europe PubMed Central

14 September 2017

Bozena Czech

2

1 reference

Europe PubMed Central

14 September 2017

Britta P Hoffmann

3

1 reference

Europe PubMed Central

14 September 2017

Marian Sujak

4

1 reference

Europe PubMed Central

14 September 2017

Timo Kahles

5

1 reference

Europe PubMed Central

14 September 2017

Helmuth Steinmetz

6

1 reference

Europe PubMed Central

14 September 2017

Tobias Neumann-Haefelin

7

1 reference

Europe PubMed Central

14 September 2017

Josef Pfeilschifter

8

1 reference

Europe PubMed Central

14 September 2017

publication date

1 June 2010

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Europe PubMed Central

14 September 2017

Neurochemical Research

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Europe PubMed Central

14 September 2017

35

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Europe PubMed Central

14 September 2017

1391-1401

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Europe PubMed Central

14 September 2017

9

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Europe PubMed Central

14 September 2017

https://scigraph.springernature.com/pub.10.1007/s11064-010-0197-0

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Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death in cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator for acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor-alpha is increased in the cerebrospinal fluid and serum of ischaemic stroke patients and correlates with the volume of evolving brain infarct.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p38 signal transduction pathway: activation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKK mediates ischemia-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,026 experimental treatments in acute stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R1--systemic thrombolysis in German stroke units--the experience from the German Stroke data bank

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain microvessel endothelial cell responses to tumor necrosis factor-alpha involve a nuclear factor kappa B (NF-kappaB) signal transduction pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of HIV progression by dithiocarb. German DTC Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple molecular penumbras after focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studying the neurovascular unit: an improved blood-brain barrier model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of endothelial monolayer permeability induced by plasma obtained from lipopolysaccharide-stimulated whole blood.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis dominant in the periinfarct area of human ischaemic stroke--a possible target of antiapoptotic treatments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viability thresholds and the penumbra of focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/20514517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-010-0197-0

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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