Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. (Q39693128)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20547678%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels (English)

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5 February 2020

4

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5 February 2020

Stefan H. Heinemann

6

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5 February 2020

author name string

Katrin Kolbe

1

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5 February 2020

Roland Schönherr

2

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5 February 2020

Guido Gessner

3

1 reference

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5 February 2020

Toshinori Hoshi

5

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5 February 2020

language of work or name

English

0 references

publication date

14 June 2010

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5 February 2020

published in

Journal of Physiology

1 reference

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5 February 2020

volume

588

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5 February 2020

page(s)

2999-3009

1 reference

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5 February 2020

issue

Pt 16

1 reference

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Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

PKA phosphorylation of HERG protein regulates the rate of channel synthesis.

15 September 2018

1 reference

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Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Sphingolipid metabolite ceramide causes metabolic perturbation contributing to HERG K+ channel dysfunction.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Functional consequences of methionine oxidation of hERG potassium channels.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications

15 September 2018

1 reference

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hERG potassium channels and cardiac arrhythmia

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Cardiac IKr channels minimally comprise hERG 1a and 1b subunits

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Functions of erg K+ channels in excitable cells.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Structural basis for modulation and agonist specificity of HCN pacemaker channels

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

The impact of drug-induced QT interval prolongation on drug discovery and development

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Impairment of human ether-à-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. Similar phenotypes but different mechanisms

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Crystal structure and mechanism of a calcium-gated potassium channel

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Hydrogen peroxide modifies the kinetics of HERG channel expressed in a mammalian cell line

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Assessment of cardiac arrhythmic risk in diabetic patients using QT dispersion abnormalities.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Regulation of the human ether-a-gogo related gene (HERG) K+ channels by reactive oxygen species

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

HERG, a human inward rectifier in the voltage-gated potassium channel family

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of reperfusion.

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956941

Diabetic cardiomyopathy: electromechanical cellular alterations

15 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20547678

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Restoring depressed HERG K+ channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20547678

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1113/JPHYSIOL.2010.192468

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20547678%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1 reference