Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use. (Q39678845)

13 September 2017

1 reference

title

Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use. (English)

1 reference

13 September 2017

1 reference

1

R N Brogden

1 reference

13 September 2017

R C Heel

2

1 reference

PubMed ID

3315622

13 September 2017

language of work or name

1 reference

1 September 1987

1 reference

13 September 2017

1 reference

13 September 2017

34

1 reference

13 September 2017

350-371

1 reference

13 September 2017

3

1 reference

https://scigraph.springernature.com/pub.10.2165/00003495-198734030-00003

13 September 2017

0 references

cites work

Fat atrophy in human insulin therapy

1 reference

12 December 2020

Transfer from porcine insulin to human insulin in insulin-dependent diabetes mellitus: effects on insulin binding to IgG and glycemic control

1 reference

12 December 2020

Human ultralente insulin

1 reference

12 December 2020

Generalised allergic reaction to human insulin

1 reference

12 December 2020

Subcutaneous use of regular human insulin (Novo): pharmacokinetics and continuous insulin infusion therapy

1 reference

12 December 2020

Receptor binding studies and clinical effects of human insulin (recombinant DNA): studies in patients with newly diagnosed type i diabetes, type II diabetes, insulin resistance (type A and type B), insulin antibodies, insulin allergy, and "brittle"

1 reference

12 December 2020

Different counterregulatory responses to human insulin (recombinant DNA) and purified pork insulin

1 reference

12 December 2020

Absorption kinetics of semisynthetic human insulin and biosynthetic (recombinant DNA) human insulin

1 reference

12 December 2020

Human insulin allergy

1 reference

12 December 2020

Desensitization with human (recombinant DNA) insulin

1 reference

12 December 2020

A multiple injection regimen using an insulin injection pen and pre-filled cartridged soluble human insulin in adolescents with diabetes

1 reference

12 December 2020

Immediate-type allergy against insulin itself: clinical and immunologic studies on a diabetic patient with insulin intolerance

1 reference

12 December 2020

Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans

1 reference

12 December 2020

Comparative studies on intermediary metabolism and hormonal counterregulation following human insulin (recombinant DNA) and purified pork insulin in man.

1 reference

12 December 2020

A comparison of biosynthetic human insulin with porcine insulin in the blood glucose control of diabetic pregnancy

1 reference

12 December 2020

Comparison of highly purified semi-synthetic insulin and highly purified porcine insulin in the treatment of type I diabetes: interim report of a multi-centre randomised single blind study

1 reference

12 December 2020

Comparison of porcine insulin and human insulin (Novo) using the glucose-controlled insulin infusion system, glucose-insulin dose-response curves, and the outpatient effectiveness of human insulin (Novo) in insulin-dependent diabetes

1 reference

12 December 2020

Biologic activity and receptor binding properties of biosynthetic human insulin in isolated rat hepatocytes and mouse soleus muscle in vitro

1 reference

12 December 2020

Insulin concentrations and time-action profiles of three different intermediate-acting insulin preparations in nondiabetic volunteers under glucose-controlled glucose infusion technique.

1 reference

12 December 2020

Immunologic improvement resulting from the transfer of animal insulin-treated diabetic subjects to human insulin (recombinant DNA)

1 reference

12 December 2020

Plasma insulin and C-peptide after subcutaneous and intravenous administration of human insulin (recombinant DNA) and purified porcine insulin in healthy men

1 reference

12 December 2020

1 reference

12 December 2020

A comparative study of the activity of biosynthetic human insulin and pork insulin using the glucose clamp technique in normal subjects

1 reference

12 December 2020

Comparison of the biologic activity of biosynthetic human insulin and natural pork insulin in juvenile-onset diabetic subjects assessed by the glucose controlled insulin infusion system

1 reference

12 December 2020

Insulin-induced lipodystrophy in diabetic patients resolved by treatment with human insulin

1 reference

12 December 2020

Successful treatment of immune-mediated insulin resistance by human insulin (recombinant DNA).

1 reference

12 December 2020

Flocculated humulin N insulin

1 reference

12 December 2020

A controlled study of prolonged study with semi-synthetic human insulin

1 reference

12 December 2020

Radioimmunoelectrophoresis in the determination of insulin binding to IgG.

1 reference

12 December 2020

Efficiency of human insulin (recombinant DNA) in the treatment of diabetic ketoacidosis and severe nonketoacidotic hyperglycemia

1 reference

12 December 2020

The subcutaneous absorption of human and bovine ultralente insulin formulations

1 reference

12 December 2020

Factors influencing the absorption, serum insulin concentration, and blood glucose responses after injections of regular insulin and various insulin mixtures.

1 reference

12 December 2020

The kinetics of insulin metabolism in diabetes mellitus

1 reference

12 December 2020

Comparative double-blind trial of the effectiveness and antigenicity of semisynthetic human insulin and purified porcine insulin in newly treated diabetic subjects

1 reference

12 December 2020

Comparison of efficacy of human and porcine insulin in treatment of diabetic ketoacidosis

1 reference

12 December 2020

Evaluation of efficacy and safety of human insulin (Novo) in the treatment of insulin-dependent diabetes mellitus: a double-blind, multicenter clinical trial

1 reference

12 December 2020

Comparison of biologic potency of human insulin (recombinant DNA) and purified porcine insulin (PPI) on the rat and human adipocyte lipogenesis model

1 reference

12 December 2020

Human insulin in the treatment of insulin allergy

1 reference

12 December 2020

Immunogenicity of highly purified bovine insulin: a comparison with conventional bovine and highly purified human insulins

1 reference

12 December 2020

A double-blind study of the efficacy of neutral human and porcine insulin in type I diabetes using a glucose-controlled insulin infusion system

1 reference

12 December 2020

Semisynthetic human insulin and purified pork insulin do not differ in their biological potency

1 reference

12 December 2020

Long-term efficacy of semi-synthetic human insulins (SHI) in newly-diagnosed insulin-dependent diabetic patients. A two year clinical study

1 reference

12 December 2020

Effects of new insulins on insulin and C-peptide antibodies, insulin dose, and diabetic control

1 reference

12 December 2020

Hepatic influence on labelled insulin metabolism

1 reference

12 December 2020

Generalised allergic reaction with synthetic human insulin

1 reference

12 December 2020

Immunogenicity of monocomponent human and porcine insulin in newly diagnosed Type 1 (insulin-dependent) diabetic children

1 reference

12 December 2020

Intradermal desensitization with human insulin (recombinant DNA) in a patient with severe allergic skin reaction due to insulin

1 reference

12 December 2020

Comparison of porcine and semisynthetic human insulins using euglycemic clamp-derived glucose-insulin dose-response curves in insulin-dependent diabetes

1 reference

12 December 2020

Comparison of the activity and pharmacokinetics of porcine insulin and human insulin (Novo) as assessed by the glucose clamp technique in normal and diabetic man

1 reference

12 December 2020

Biologic activities of biosynthetic human insulin in healthy volunteers and insulin-dependent diabetic patients monitored by the artificial endocrine pancreas

1 reference

12 December 2020

Semisynthetic Human Insulin: Biologic and Immunologic Activity in Newly Treated Diabetic Subjects During a Six-month Follow-up

1 reference

12 December 2020

Biosynthetic human insulin: effect in healthy men on plasma glucose and non-esterified fatty acids in comparison with highly purified pork insulin

1 reference

12 December 2020

Human insulin and porcine insulin in the treatment of diabetic children: comparison of metabolic control and insulin antibody production

1 reference

12 December 2020

Potency of biosynthetic human insulin determined in vitro

1 reference

12 December 2020

Human Monotard insulin: dose-dependent subcutaneous absorption

1 reference

12 December 2020

Comparison of the Biologic Activity of Porcine and Semisynthetic Human Insulins Using the Glucose-controlled Insulin Infusion System in Insulin-dependent Diabetes

1 reference

12 December 2020

Specificity of immunoglobulin E and immunoglobulin G against human (recombinant DNA) insulin in human insulin allergy and resistance.

1 reference

12 December 2020

Comparative study of NPH human insulin (recombinant DNA) and NPH bovine insulin in diabetic subjects

1 reference

12 December 2020

Comparison of human versus porcine insulin in treatment of diabetes in children

1 reference

12 December 2020

Allergy to purified bovine, porcine, and human insulins

1 reference

12 December 2020

Comparative study of subcutaneous, intramuscular, and intravenous administration of human insulin

1 reference

12 December 2020

Insulin-specific IgE in serum of 67 diabetic patients against human insulin (Novo), porcine insulin, and bovine insulin. Four case reports

1 reference

12 December 2020

Human and porcine regular insulins are equally effective in subcutaneous replacement therapy. Results of a double-blind crossover study in type I diabetic patients with continuous subcutaneous insulin infusion

1 reference

12 December 2020

A comparison of semisynthetic human insulin and porcine insulin in the treatment of established diabetes

1 reference

12 December 2020

Comparative clinical pharmacology of human insulin (Novo) and porcine insulin in normal subjects

1 reference

12 December 2020

Insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man

1 reference

12 December 2020

Comparative analysis of soluble porcine and human insulin (Novo) using the artificial pancreas

1 reference

12 December 2020

A comparison of semisynthetic human NPH insulin and porcine NPH insulin in the treatment of insulin-dependent diabetes mellitus.

1 reference

12 December 2020

A comparison of the activity and disposal of semi-synthetic human insulin and porcine insulin in normal man by the glucose clamp technique

1 reference

12 December 2020

Inhibition of pancreatic glucagon responses to arginine by human insulin (recombinant DNA) and purified porcine insulin in normal and diabetic subjects

1 reference

12 December 2020

Kinetics and Metabolic Activity of Biosynthetic NPH Insulin Evaluated by the Glucose Clamp Technique

1 reference

12 December 2020

A comparison of the uptake of human and porcine insulins given intraperitoneally to patients with diabetes mellitus on continuous ambulatory peritoneal dialysis

1 reference

12 December 2020

Human ultralente insulin: a comparison with porcine lente insulin as a twice-daily insulin in insulin-dependent diabetic patients with fasting hyperglycaemia.

1 reference

12 December 2020

Human, porcine and bovine ultralente insulin: subcutaneous administration in normal man

1 reference

12 December 2020

Metabolic clearance of insulin in man.

1 reference

12 December 2020

Comparative study of NPH human insulin (recombinant DNA) and pork insulin in diabetic subjects: preliminary report

1 reference

12 December 2020

Comparison of biosynthetic human insulin and pork insulin during rest, food ingestion, and physical work in insulin-dependent diabetic subjects using a glucose controlled insulin infusion system

1 reference

12 December 2020

Cutaneous allergy to human (recombinant DNA) insulin

1 reference

12 December 2020

An immunochemical method for the quantitation of insulin antibodies

1 reference

12 December 2020

A comparison of the effects of semisynthetic human insulin and porcine insulin on transmembrane ion shifts and glucose metabolism during euglycaemic clamping

1 reference

12 December 2020

Studies on the biologic actions of biosynthetic human insulin in vitro and in diabetic man

1 reference

12 December 2020

Treatment with human insulin (recombinant DNA) in diabetic subjects pretreated with pork or beef insulin: first results of a multicenter study.

1 reference

12 December 2020

Absorption kinetics and biologic effects of subcutaneously injected insulin preparations

1 reference

12 December 2020

Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects.

1 reference

12 December 2020

A model of the kinetics of insulin in man.

1 reference

12 December 2020

Immunoreactivity of Human Insulin of Recombinant DNA Origin

1 reference

12 December 2020

A comparison of the biological actions and pharmacokinetics of intravenously infused highly purified beef and biosynthetic human insulins in normal man

1 reference

12 December 2020

Metabolic profiles in diabetic subjects treated with human insulin (Novo) and porcine insulin

1 reference

12 December 2020

Biosynthetic human insulin in the treatment of diabetes. A double-blind crossover trial in established diabetic patients.

1 reference

12 December 2020

Receptor binding of biosynthetic human insulin on isolated pig hepatocytes

1 reference

12 December 2020

Primary allergy to monocomponent porcine insulin

1 reference

12 December 2020

Binding of biosynthetic human insulin to erythrocytes of normal and insulin-dependent diabetic subjects: comparison with pork and human pancreatic insulin

1 reference

12 December 2020

Less pronounced changes in serum potassium and epinephrine during hypoglycemia induced by human insulin (recombinant DNA)

1 reference

12 December 2020

The biological properties of human insulin. Subcutaneous absorption, receptor binding and the clinical effect in diabetics assessed by a new statistical method

1 reference

12 December 2020

The therapeutic efficacy of human insulin (recombinant DNA) in patients with insulin-dependent diabetes mellitus: a comparative study with purified porcine insulin

1 reference

12 December 2020

Immunogenicity of recombinant DNA human insulin

1 reference

12 December 2020

Human insulin produced by recombinant DNA technology: safety and hypoglycaemic potency in healthy men

1 reference

12 December 2020

Pharmacokinetics of biosynthetic human insulin and characteristics of its effect

1 reference

12 December 2020

Influence of insulin antibodies on pharmacokinetics and bioavailability of recombinant human and highly purified beef insulins in insulin dependent diabetics

1 reference

12 December 2020

Insulin allergy treated with human insulin (recombinant DNA).

1 reference

12 December 2020

Porcine and human insulin (Novo): a comparison of their metabolism and hypoglycemic activity in normal man

1 reference

12 December 2020

Biosynthetic human insulin does not modify circulating lipid and apolipoprotein concentrations in type I diabetic patients.

1 reference

12 December 2020

Clinical pharmacologic studies with human insulin (recombinant DNA).

1 reference

12 December 2020

Human and porcine insulins are equally effective in the regulation of glucose kinetics of diabetic patients during exercise

1 reference

12 December 2020

A Fifteen-month Double-blind Cross-over Study of the Efficacy and Antigenicity of Human and Pork Insulins

1 reference

12 December 2020

Immunogenicity of semisynthetic human insulin in man. Long-term comparison with porcine monocomponent insulin

1 reference

12 December 2020

The plasma glucose response of normal fasting subjects to neutral regular and NPH biosynthetic human and purified pork insulins.

1 reference

12 December 2020

The effect of insulin antibodies on insulin dose and diabetic control

1 reference

12 December 2020

Immunogenicity of human insulin (Novo) or pork monocomponent insulin in HLA-DR-typed insulin-dependent diabetic individuals

1 reference

12 December 2020

Biologic and immunologic in vivo and in vitro studies with biosynthetic human insulin

1 reference

12 December 2020

Dose-dependent Subcutaneous Absorption of Porcine, Bovine and Human NPH Insulins

1 reference

12 December 2020

Receptor binding properties and biologic activity in vitro of biosynthetic human insulin.

1 reference

12 December 2020

Preliminary studies on the immunogenicity and amount of Escherichia coli polypeptides in biosynthetic human insulin produced by recombinant DNA technology

1 reference

12 December 2020

The U.S. "new patient" and "transfer" studies.

1 reference

12 December 2020

Clinical pharmacology of human insulin of recombinant DNA origin in healthy volunteers.

1 reference

12 December 2020

10.2165/00003495-198734030-00003

Identifiers

DOI

1 reference

PubMed ID

3315622

Dimensions Publication ID

13 September 2017

0 references

1 reference

PubMed ID

3315622