BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets (Q39674825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12024039%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets (English)

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9 November 2019

3

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9 November 2019

2

Rishu Takimoto

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9 November 2019

author name string

Timothy K MacLachlan

series ordinal

1

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9 November 2019

language of work or name

English

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publication date

1 June 2002

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Molecular and Cellular Biology

9 November 2019

published in

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9 November 2019

volume

22

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9 November 2019

page(s)

4280-4292

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9 November 2019

issue

12

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Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis

9 November 2019

cites work

1 reference

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Redistribution of BRCA1 among four different protein complexes following replication blockage

14 September 2017

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Role of BRCA gene dysfunction in breast and ovarian cancer predisposition

14 September 2017

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Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

14 September 2017

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Lessons learned from BRCA1 and BRCA2.

14 September 2017

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The DNA damage response: putting checkpoints in perspective

14 September 2017

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

14 September 2017

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

14 September 2017

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Tumor suppressor p53 is required to modulate BRCA1 expression

14 September 2017

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A ribonucleotide reductase gene is a transcriptional target of p53 and p73

14 September 2017

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

14 September 2017

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PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

14 September 2017

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

14 September 2017

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Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

14 September 2017

1 reference

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Genetic analysis of BRCA1 function in a defined tumor cell line

14 September 2017

1 reference

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BRCA1 signals ARF-dependent stabilization and coactivation of p53.

14 September 2017

1 reference

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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

14 September 2017

1 reference

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

14 September 2017

1 reference

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

14 September 2017

1 reference

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Expression monitoring by hybridization to high-density oligonucleotide arrays

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

A simplified system for generating recombinant adenoviruses

14 September 2017

1 reference

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BRCA1 regulates p53-dependent gene expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

14 September 2017

1 reference

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A model for p53-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

14 September 2017

1 reference

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Characterisation of human cyclin G1 and G2: DNA damage inducible genes

14 September 2017

1 reference

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

14 September 2017

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WAF1, a potential mediator of p53 tumor suppression

14 September 2017

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

14 September 2017

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

14 September 2017

1 reference

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Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.

14 September 2017

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Comparative gene expression profiling in response to p53 in a human lung cancer cell line.

25 September 2017

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A role of cyclin G in the process of apoptosis

25 September 2017

1 reference

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Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

25 September 2017

1 reference

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Repression of BRCA1 through a feedback loop involving p53.

25 September 2017

1 reference

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p21/p53, cellular growth control and genomic integrity

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133857

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

21 August 2018

1 reference

12 December 2020

A novel p53 germline alteration identified in a late onset breast cancer kindred

1 reference

12 December 2020

BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer

1 reference

12 December 2020

Genome-wide expression monitoring in Saccharomyces cerevisiae

1 reference

12 December 2020

Genomic instability in Gadd45a-deficient mice

1 reference

12 December 2020

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1 reference

12 December 2020

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2

1 reference

12 December 2020

Mammary tumor formation in p53- and BRCA1-deficient mice

1 reference

12 December 2020

10.1128/MCB.22.12.4280-4292.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12024039%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12024039%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference