Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer (Q39657784)

13 September 2017

Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer (English)

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13 September 2017

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Jeffrey J Wallin

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13 September 2017

Jane Guan

2

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13 September 2017

Wei Wei Prior

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13 September 2017

Kyle A Edgar

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13 September 2017

Robert Kassees

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13 September 2017

Deepak Sampath

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13 September 2017

Marcia Belvin

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13 September 2017

Lori S Friedman

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13 September 2017

language of work or name

English

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publication date

1 September 2010

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Science Translational Medicine

13 September 2017

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13 September 2017

2

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13 September 2017

48

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13 September 2017

48ra66

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Oncogenic PI3K deregulates transcription and translation

13 September 2017

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Activation of Akt predicts poor outcome in neuroblastoma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Flow cytometric analysis of the cell cycle phase specificity of DNA damage induced by radiation, hydrogen peroxide and doxorubicin.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Cell death by mitotic catastrophe: a molecular definition

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

AKT/PKB signaling: navigating downstream

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Cdc25 and Wee1: analogous opposites?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Enhanced anti-cancer effect of a phosphatidylinositol-3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000630

10.1126/SCITRANSLMED.3000630

21 January 2018

Identifiers

DOI

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13 September 2017

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