Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis (Q39653516)

13 September 2017

Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis (English)

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13 September 2017

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M Hörnle

1

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13 September 2017

N Peters

2

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13 September 2017

B Thayaparasingham

3

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13 September 2017

H Vörsmann

4

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13 September 2017

H Kashkar

5

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13 September 2017

D Kulms

6

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13 September 2017

language of work or name

English

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publication date

20 September 2010

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13 September 2017

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13 September 2017

30

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13 September 2017

5

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13 September 2017

575-587

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https://scigraph.springernature.com/pub.10.1038/onc.2010.434

13 September 2017

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cites work

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Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination

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The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways

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Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins

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Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

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Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9

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Impact of XIAP protein levels on the survival of myeloma cells

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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An IAP-IAP complex inhibits apoptosis

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Chemotherapy and targeted therapy combinations in advanced melanoma

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Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein

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XIAP as a ubiquitin ligase in cellular signaling

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Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

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Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis.

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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

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The inhibitors of apoptosis (IAPs) as cancer targets

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Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells.

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Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway

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NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs

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XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

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Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane.

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The promise of TRAIL--potential and risks of a novel anticancer therapy

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The incidence and mortality of cutaneous melanoma in Southern Germany: trends by anatomic site and pathologic characteristics, 1976 to 2003.

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Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation

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Prostacyclin inhibits endothelial cell XIAP ubiquitination and degradation

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Proteasome inhibitors prevent cisplatin-induced mitochondrial release of apoptosis-inducing factor and markedly ameliorate cisplatin nephrotoxicity.

31 March 2020

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Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

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Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation

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Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

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X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO

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A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma

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Targeting XIAP for the treatment of malignancy

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Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells

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Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

31 March 2020

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Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

The proteasome is required for rapid initiation of death receptor-induced apoptosis

31 March 2020

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31 March 2020

IAPs: what's in a name?

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Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

31 March 2020

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Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

Caspase-9 cleavage, do you need it?

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.434

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.434

Resistance of human melanoma cells against the death ligand TRAIL is reversed by ultraviolet-B radiation via downregulation of FLIP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.434

Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.434

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.434

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Dimensions Publication ID

13 September 2017

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