A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer. (Q39621147)

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scientific article published on 13 December 2010

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English	A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.	scientific article published on 13 December 2010

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scholarly article

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Europe PubMed Central

13 September 2017

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer (English)

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13 May 2020

Timothy L Frankel

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Nicholas P. Restifo

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Steven Rosenberg

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Steven A Rosenberg

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Steven R. Feldman

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Mahadev Rao

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David S Schrump

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David S Schrump

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Nachimuthu Chinnasamy

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Jennifer A Wargo

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13 May 2020

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Zhiya Yu

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13 May 2020

John P Riley

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Jenny J Hong

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Maria R Parkhurst

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Paul F Robbins

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Richard A Morgan

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publication date

13 December 2010

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Journal of Immunology

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13 May 2020

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13 May 2020

High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Induction of MAGE-3 expression in lung and esophageal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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GSK's antigen-specific cancer immunotherapy programme: pilot results leading to Phase III clinical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

1 reference

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12 December 2020

based on heuristic

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Tissue microarray evaluation of Melanoma antigen E (MAGE) tumor-associated antigen expression: potential indications for specific immunotherapy and prognostic relevance in squamous cell lung carcinoma

1 reference

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12 December 2020

based on heuristic

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Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine

1 reference

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12 December 2020

based on heuristic

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Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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MAGRIT: the largest-ever phase III lung cancer trial aims to establish a novel tumor-specific approach to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Melanoma cells present a MAGE-3 epitope to CD4(+) cytotoxic T cells in association with histocompatibility leukocyte antigen DR11.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Coordinated expression of clustered cancer/testis genes encoded in a large inverted repeat DNA structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

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A new era for cancer immunotherapy based on the genes that encode cancer antigens

1 reference

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12 December 2020

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cancer/testis (CT) antigens in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Cancer testis antigens--their importance in immunotherapy and in the early detection of cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

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Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multi-epitope approach for immunotherapy for cancer: identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4(+) T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunotherapy: a treatment for the masses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-reactive T helper lymphocytes recognize a promiscuous MAGE-A3 epitope presented by various major histocompatibility complex class II alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination of a melanoma patient with mature dendritic cells pulsed with MAGE-3 peptides triggers the activity of nonvaccine anti-tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of CTL recognizing an HLA-A*0201-restricted epitope shared by MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 tumor antigens: implication in a broad-spectrum tumor immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A MAGE-A3 peptide presented by HLA-DP4 is recognized on tumor cells by CD4+ cytolytic T lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in human tumour immunology and immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAGE-A3 is a frequent tumor antigen of metastasized melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer/testis antigens, gametogenesis and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cancer-testis genes in human hepatocellular carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An overview of the MAGE gene family with the identification of all human members of the family

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid identity and/or position determines the proteasomal cleavage of the HLA-A*0201-restricted peptide tumor antigen MAGE-3271-279.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer/testis (CT) antigens: potential targets for immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21149604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1001775

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6292200&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6292200&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6292200&resulttype=core&format=json

13 May 2020

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