A complex regulatory network of transcription factors critical for ocular development and disease. (Q39600052)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21282189%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

A complex regulatory network of transcription factors critical for ocular development and disease (English)

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21 January 2020

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GOA release 2020-03-11

Forkhead box C1b

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Paired-like homeodomain 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Ted Allison

4

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21 January 2020

author name string

Moulinath Acharya

1

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21 January 2020

Lijia Huang

2

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21 January 2020

Valerie C Fleisch

3

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21 January 2020

Michael A Walter

5

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21 January 2020

language of work or name

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31 January 2011

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21 January 2020

published in

Human Molecular Genetics

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21 January 2020

volume

20

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21 January 2020

issue

8

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21 January 2020

page(s)

1610-1624

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Pitx1 and Pitx2 are required for development of hindlimb buds.

21 January 2020

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Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3

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Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

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Forkhead transcription factors: key players in development and metabolism

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Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations.

21 January 2018

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Molecular genetics of Axenfeld-Rieger malformations

21 January 2018

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Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene

21 January 2018

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Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome

21 January 2018

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Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

21 January 2018

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A novel mechanistic spectrum underlies glaucoma-associated chromosome 6p25 copy number variation

21 January 2018

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Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma

21 January 2018

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A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye

21 January 2018

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The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions

21 January 2018

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Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1

21 January 2018

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Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1

21 January 2018

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Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.

21 January 2018

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Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome

21 January 2018

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The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis

21 January 2018

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The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus

21 January 2018

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The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis

21 January 2018

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Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis

21 January 2018

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Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells

21 January 2018

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Regulation of cancer cell survival by Par-4.

21 January 2018

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A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

21 January 2018

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FGF19 is a target for FOXC1 regulation in ciliary body-derived cells

21 January 2018

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FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A

21 January 2018

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FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis

21 January 2018

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Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

21 January 2018

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Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish.

21 January 2018

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p53 activation by knockdown technologies

21 January 2018

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Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly

21 January 2018

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Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development

21 January 2018

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Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions

21 January 2018

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The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

21 January 2018

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Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones

21 January 2018

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Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells

21 January 2018

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Tbx1 is regulated by forkhead proteins in the secondary heart field

21 January 2018

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Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer

21 January 2018

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Apoptosis by Par-4 in cancer and neurodegenerative diseases

21 January 2018

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Classification of left-right patterning defects in zebrafish, mice, and humans

21 January 2018

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Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development

21 January 2018

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Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors

21 January 2018

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Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDR038

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21282189%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference