Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. (Q39584429)

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scientific article published on March 2011

Language	Label	Description	Also known as
English	Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.	scientific article published on March 2011

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scholarly article

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23 January 2020

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model (English)

1 reference

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23 January 2020

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inferred from title

angiogenesis inhibitor

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based on heuristic

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tumour xenograft

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based on heuristic

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Manuel Vincente Sanchez-Felix

17

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23 January 2020

author name string

Timothy P Burkholder

1

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23 January 2020

Joshua R Clayton

2

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23 January 2020

Mark E Rempala

3

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23 January 2020

James R Henry

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23 January 2020

John M Knobeloch

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23 January 2020

David Mendel

6

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23 January 2020

Johnathan A McLean

7

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Yan Hao

8

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David A Barda

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Eileen L Considine

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23 January 2020

Mark T Uhlik

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23 January 2020

Yuefeng Chen

12

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23 January 2020

Liandong Ma

13

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23 January 2020

Laura J Bloem

14

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23 January 2020

Jacqueline K Akunda

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23 January 2020

Denis J McCann

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23 January 2020

David K Clawson

18

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23 January 2020

Michael M Lahn

19

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23 January 2020

James J Starling

20

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publication date

1 March 2011

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Investigational New Drugs

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3

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936-949

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23 January 2020

https://scigraph.springernature.com/pub.10.1007/s10637-011-9640-6

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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

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The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

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Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

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Vascular-specific growth factors and blood vessel formation

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A general strategy for creating "inactive-conformation" abl inhibitors

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis

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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

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Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors

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Development of a Transcreener kinase assay for protein kinase A and demonstration of concordance of data with a filter-binding assay format

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Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA

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Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

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Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

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Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate

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Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans

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Cutaneous side-effects of kinase inhibitors and blocking antibodies

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Tyrosine kinase inhibition and grey hair

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21 January 2018

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

1 reference

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Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360050

12 December 2020

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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

1 reference

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1 reference

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Identifiers

10.1007/S10637-011-9640-6

1 reference

Europe PubMed Central

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23 January 2020

1 reference

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23 January 2020

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