Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties (Q39525144)

12 September 2017

Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties (English)

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12 September 2017

Andrew Schally

4

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Theodora Katsila

2

object named as

Theodora Katsila

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12 September 2017

Despina Laimou

1

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12 September 2017

John Matsoukas

3

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12 September 2017

Kostas Gkountelias

5

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12 September 2017

George Liapakis

6

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12 September 2017

Constantin Tamvakopoulos

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12 September 2017

Theodore Tselios

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12 September 2017

4 October 2012

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European Journal of Medicinal Chemistry

12 September 2017

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12 September 2017

58

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12 September 2017

237-247

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Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. I. Native decapeptide

12 September 2017

1 reference

11 October 2022

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Mass spectrometry for the quantification of bioactive peptides in biological fluids

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11 October 2022

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Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones

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11 October 2022

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In vivo evaluation and in vitro metabolism of leuprolide in mice--mass spectrometry-based biomarker measurement for efficacy and toxicity

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Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III

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11 October 2022

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Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides

1 reference

11 October 2022

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Structural comparison between type I and type II antagonists: possible implications in the drug design of AT1 antagonists

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An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies

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Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities

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Use of analogs of peptide hormones conjugated to cytotoxic radicals for chemotherapy targeted to receptors on tumors.

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Gonadotropin-releasing hormone receptors

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11 October 2022

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Receptor-mediated tumor targeting based on peptide hormones

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Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.

1 reference

11 October 2022

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Identification of new gonadotrophin-releasing hormone partial agonists

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Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease

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Gonadotropin-releasing hormone and its analogues

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Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: preclinical evaluation of DP-IV inhibitors.

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Molecular mechanism of gonadotropin releasing hormone (GnRH) action. I. The GnRH receptor

1 reference

11 October 2022

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Comparison of Proposed Putative Active Conformations of Myelin Basic Protein Epitope 87−99 Linear Altered Peptide Ligands by Spectroscopic and Modelling Studies: The Role of Positions 91 and 96 in T-Cell Receptor Activation

1 reference

11 October 2022

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Antagonistic Effects of Human Cyclic MBP87-99Altered Peptide Ligands in Experimental Allergic Encephalomyelitis and Human T-Cell Proliferation

1 reference

11 October 2022

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GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6.

1 reference

11 October 2022

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Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis

1 reference

11 October 2022

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Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor

1 reference

11 October 2022

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Evaluation of a stable gonadotropin-releasing hormone analog in mice for the treatment of endocrine disorders and prostate cancer

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Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives

1 reference

11 October 2022

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Molecular dynamics at the receptor level of immunodominant myelin basic protein epitope 87–99 implicated in multiple sclerosis and its antagonists altered peptide ligands: Triggering of immune response

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11 October 2022

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Identification of ligand binding determinants in the somatostatin receptor subtypes 1 and 2

1 reference

11 October 2022

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Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists

1 reference

11 October 2022

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Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats

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11 October 2022

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Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: rational design, synthesis and biological evaluation

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Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: importance of the Phe/Arg relative conformation and the primary amino group for activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

Design, synthesis, and molecular modeling of a novel amide-linked cyclic GnRH analogue cyclo(4-9)[Lys4,D-Trp6,Glu9]GnRH: stimulation of gonadotropin gene expression

1 reference

11 October 2022

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Design and synthesis of a potent cyclic analogue of the myelin basic protein epitope MBP72-85: importance of the Ala81 carboxyl group and of a cyclic conformation for induction of experimental allergic encephalomyelitis

1 reference

11 October 2022

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Design of novel cyclic altered peptide ligands of myelin basic protein MBP83-99 that modulate immune responses in SJL/J mice

1 reference

11 October 2022

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Novel synthesis of cyclic amide-linked analogues of angiotensins II and III

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11 October 2022

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Effectiveness, pharmacokinetics, and safety of a new sustained-release leuprolide acetate 3.75-mg depot formulation for testosterone suppression in patients with prostate cancer: a Phase III, open-label, international multicenter study

1 reference

11 October 2022

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A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis.

1 reference

11 October 2022

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Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II.

1 reference

11 October 2022

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Structural elucidation of Leuprolide and its analogues in solution: insight into their bioactive conformation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

A putative bioactive conformation for the altered peptide ligand of myelin basic protein and inhibitor of experimental autoimmune encephalomyelitis [Arg91, Ala96] MBP87-99.

1 reference

11 October 2022

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LH-RH analogues: I. Their impact on reproductive medicine

1 reference

11 October 2022

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Luteinizing hormone-releasing hormone analogs: their impact on the control of tumorigenesis

1 reference

11 October 2022

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The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes

1 reference

11 October 2022

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Conformational analysis of the molecule luteinizing hormone-releasing hormone. 3. Analog inhibitors and antagonists

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.EJMECH.2012.09.043

Identifiers

DOI

10.1016/J.EJMECH.2012.09.043

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12 September 2017

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