Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo (Q39515479)

12 September 2017

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo (English)

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12 September 2017

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Ninib Baryawno

2

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Malin Wickström

object named as

Malin Wickström

4

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Per Kogner

object named as

Per Kogner

6

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author name string

Lova Segerström

1

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12 September 2017

Baldur Sveinbjörnsson

3

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12 September 2017

Lotta Elfman

5

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12 September 2017

John Inge Johnsen

7

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12 September 2017

language of work or name

English

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publication date

29 August 2011

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International Journal of Cancer

12 September 2017

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12 September 2017

129

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12 September 2017

2958-2965

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12 September 2017

12

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Embryonal neural tumours and cell death

12 September 2017

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Neuroblastoma: biological insights into a clinical enigma

21 January 2018

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21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

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Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo

21 January 2018

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Activation of Akt predicts poor outcome in neuroblastoma

21 January 2018

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

21 January 2018

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From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors

21 January 2018

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

21 January 2018

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

21 January 2018

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Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

21 January 2018

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The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

21 January 2018

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PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

21 January 2018

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Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth

21 January 2018

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OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms

21 January 2018

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A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism

21 January 2018

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OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells

21 January 2018

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OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma

21 January 2018

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Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

21 January 2018

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Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress.

21 January 2018

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Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.

21 January 2018

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Medulloblastoma: a disease with disorganized developmental signaling cascades.

21 January 2018

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Childhood tumors of the nervous system as disorders of normal development

21 January 2018

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

21 January 2018

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The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

21 January 2018

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Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma

21 January 2018

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Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

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Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest

21 January 2018

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Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expression

21 January 2018

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In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine

21 January 2018

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21 January 2018

Drugging the PI3 kinome.

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Essential role of PDK1 in regulating cell size and development in mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.26268

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12 September 2017

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