Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration (Q39514532)

12 September 2017

Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration (English)

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non-small-cell lung carcinoma

12 September 2017

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Myoung W Lee

1

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12 September 2017

Dae S Kim

2

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12 September 2017

Joo H Lee

3

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12 September 2017

Bum S Lee

4

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12 September 2017

Soo H Lee

5

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12 September 2017

Hye L Jung

6

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12 September 2017

Ki W Sung

7

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12 September 2017

Heung T Kim

8

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12 September 2017

Keon H Yoo

9

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12 September 2017

Hong H Koo

10

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12 September 2017

5 August 2011

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12 September 2017

102

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1822-1828

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12 September 2017

10

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

12 September 2017

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by alphav-integrins and the IGF-I receptor.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt isoform-specific inhibition of MDA-MB-231 cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02025.X

10.1111/J.1349-7006.2011.02025.X

21 January 2018

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DOI

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12 September 2017

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