Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1. (Q39510567)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900321%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1 (English)

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20 March 2020

1

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20 March 2020

author name string

Jian-Cheng Li

2

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20 March 2020

Michael P Pence

3

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20 March 2020

E Michael Gibbs

4

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20 March 2020

Jennifer L LaPerle

5

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20 March 2020

John Litchfield

6

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20 March 2020

David W Piotrowski

7

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20 March 2020

Michael J Munchhof

8

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20 March 2020

Tara B Manion

9

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20 March 2020

William J Zavadoski

10

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20 March 2020

Gregory S Walker

11

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20 March 2020

R Kirk McPherson

12

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20 March 2020

Susan Tapley

13

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20 March 2020

Eliot Sugarman

14

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20 March 2020

Angel Guzman-Perez

15

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20 March 2020

Paul DaSilva-Jardine

16

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20 March 2020

publication date

18 March 2011

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ACS Medicinal Chemistry Letters

20 March 2020

published in

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volume

2

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page(s)

407-412

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20 March 2020

issue

5

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DGAT1 inhibitors as anti-obesity and anti-diabetic agents.

20 March 2020

cites work

1 reference

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Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents

12 September 2017

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Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?

12 September 2017

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Diacylglycerol acyltransferases: Potential roles as pharmacological targets

12 September 2017

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Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis

12 September 2017

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Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

12 September 2017

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Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions

12 September 2017

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Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

12 September 2017

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Prediction of a new drug's potential to cause idiosyncratic reactions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

CDER photosafety guidance for industry

12 September 2017

1 reference

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Coenzyme A: diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets.

15 June 2018

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Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor

21 August 2018

1 reference

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Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

21 August 2018

1 reference

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Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac

21 August 2018

1 reference

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Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

21 August 2018

1 reference

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Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

21 August 2018

1 reference

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Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018057

Metabolic activation of carboxylic acids

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML200051P

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900321%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900321%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference